研究方向：  1、基于树状大分子的纳米医学：  a. 有机/无机纳米复合材料的合成及其在肿瘤分子影像诊断中的应用；  b. 纳米药物输送体系的制备与抗肿瘤效果评价；  c. 有机/无机杂化纳米颗粒用于基因传递的研究。 2、静电纺纳米纤维材料在生物医学与环境科学中的应用。 Telephone：021-67792750     EMAIL：mwshen@dhu.edu.cn

个人简介：

沈明武，化学化工与生物工程学院生物工程系研究员，博士生导师。2001年毕业于清华大学，获工学博士。2008年回国前，在美国密歇根大学历任访问学者和副研究员。多年来主要从事纳米医学与生物材料技术等领域的应用基础研究，内容主要涉及了杂化纳米材料的肿瘤单模态CT、MR成像，或双模态CT/MR、SPECT/CT和SPECT/MR成像、以及作为化疗药物、基因和光热转换剂的载体用于肿瘤化疗、基因、光热以及联合治疗。到目前为止，申请人共发表或接收了SCI期刊论文200余篇（h-指数57），5篇书的章节，并获授权中国发明专利19项。近五年（2015-2020）共发表或接受SCI收录期刊论文100篇（IF>4的有67篇，IF>7的有19篇），其中第一（或通讯）作者SCI收录论文48篇，IF大于8的有12篇，包括Chem. Soc. Rev.1篇、Adv. Sci. 2篇、Small 1篇、Biomaterials 1篇、ACS Appl. Mater. Interface 5篇、Chem. Eng. J. 1篇、Adv. Colloid Interface Sci. 1篇。获授权专利13项。

荣誉及获奖情况：

1. 2000年：中国高校科学技术奖一等奖。

2. 2001年：国家自然科学奖二等奖。

3. 2010年：高校科学研究优秀成果奖自然科学奖一等奖。

4. 2016年：中国医疗保健国际交流促进会华夏医学科技奖二等奖。

5. 2017年：中华医学科技奖三等奖。

6. 2017年：上海市科技进步奖一等奖。

7. 2018年：上海市自然科学奖一等奖。
   

近年来承担的主要科研项目：

1. 磁性氧化铁/金核壳纳米颗粒的构建及其CT/MRI双重模式肿瘤成像诊断研究, 国家自然科学基金青年基金（81101150），2012.1-2014.12，项目主持人。

2. 基于树状大分子的多功能复合纳米颗粒分子影像探针的构建及其双模态肿瘤靶向成像诊断（12520705500），上海市科委国际合作项目，2012.10-2014.9，项目主持人。

3. 基于超支化聚乙烯亚胺的多功能纳米平台的构建及其肿瘤诊断与治疗应用（81341050），国家自然科学基金主任基金，2014.1-2014.12，项目主持人。

4. 利用超支化聚合物构建纳米凝胶平台及其肿瘤CT/MRI双模态成像诊断研究，中央高校，2015.1-2017.12，项目主持人。

5. 利用支化聚乙烯亚胺构建多功能双模态SPECT/CT 纳米探针及其肿瘤影像诊断应用, 上海市科委政府间国际合作项目(15520711400)，2015.10-2018.9，项目主持人。

6. 螯合铜离子的多功能核壳树状大分子的组装合成及其脑胶质瘤精准诊疗应用，上海市科委“一带一路”国际科技合作基金项目（19410740200），2019.11-2021.10，项目主持人

近五年（2015-2020）代表论著和专利：

1. Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* Xiangyang Shi*. Hyaluronic Acid-Modified Fe3O4@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials 2015, 38, 10-21 (impact factor 10.273, citation #7).

2. Qian Chen, Han Wang, Hui Liu, Shihui Wen, Chen Peng, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Multifunctional Dendrimer-Entrapped Gold Nanoparticles Modified with RGD Peptide for Targeted Computed Tomography/Magnetic Resonance Dual-Modal Imaging of Tumors. Anal. Chem. 2015, 87 (7), pp 3949–3956 (Impact factor 6.350, citation #1).

3. Yong Hu, Jingchao Li, Jia Yang, Ping Wei, Yu Luo, Ling Ding, Wenjie Sun, Guixiang Zhang*, Xiangyang Shi*, Mingwu Shen*. Facile synthesis of RGD peptide-modified iron oxide nanoparticles with ultrahigh relaxivity for targeted MR imaging of tumors. Biomater. Sci. 2015, 3, 721-732 (impact factor 5.251, citation #1).

4. Jingchao Li, Yong Hu, Jia Yang, Wenjie Sun, Hongdong Cai, Ping Wei, Yaping Sun,* Guixiang Zhang, Xiangyang Shi*, Mingwu Shen*. Facile synthesis of folic acid-functionalized iron oxide nanoparticles with ultrahigh relaxivity for targeted tumor MR imaging. J. Mater. Chem. B 2015, 3, 5720 - 5730 (Impact factor 5.047). 

5. Yu Luo, Jia Yang, Yu Yan, Jingchao Li, Mingwu Shen,* Guixiang Zhang,* Serge Mignani, Xiangyang Shi*. RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T1-weighted MR imaging of glioma. Nanoscale 2015, 7, 14538–14546 (impact factor 6.970). 

6. Hongdong Cai, Kangan Li, Jingchao Li, Shihui Wen, Qian Chen, Mingwu Shen,* Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Dendrimer-Assisted Formation of Fe3O4/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors. Small 2015, 11 (35), 4584-4593 (impact factor 10.856). 

7. Hongdong Cai, Xiao An, Shihui Wen, Jingchao Li, Guixiang Zhang*, Xiangyang Shi*, Mingwu Shen*. Facile One-Pot Synthesis of Gd(OH)3-Doped Fe3O4 Nanoparticles for Dual-Mode T1- and T2-Weighted Magnetic Resonance Imaging Applications. Part. Part. Syst. Charact. 2015, 32(10):934-943 (impact factor 4.194). 

8. Jingyi Zhu, Lingzhou Zhao, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Mingwu Shen, Jinhua Zhao,* and Xiangyang Shi*. Radionuclide 131I-Labeled Multifunctional Dendrimers for Targeted SPECT Imaging and Radiotherapy of Tumors. Nanoscale 2015, in press (impact factor  6.970). 

9. Yong Hu, Jia Yang, Ping Wei, Jingchao Li, Ling Ding, Guixiang Zhang,* Xiangyang Shi,* Mingwu Shen*. Facile synthesis of hyaluronic acid-modified Fe3O4/Au composite nanoparticles for targeted dual mode MR/CT imaging of tumors. J. Mater. Chem. B 2015, 3, 9098-9108 (Impact factor 5.047). 

10. Lei Liu, Yili Zhao, Qian Chen, Xiangyang Shi,* Mingwu Shen*. The assembly of polyethyleneimine-entrapped gold nanoparticles onto filter paper for catalytic applications. RSC Adv. 2015, 5, 104239 - 104244 (impact factor  3.049).

11. Jingchao Li, Yong Hu, Wenjie Sun, Yu Luo, Xiangyang Shi,* Mingwu Shen*. Facile preparation of hyaluronic acid-modified Fe3O4@Mn3O4 nanocomposites for targeted T1/T2 dual-mode MR imaging of cancer cells. RSC Adv. 2016, 6, 35295-35304 (impact factor 3.049, citation #9). 

12. Benqing Zhou, Mingwu Shen*, István Bányai,* Xiangyang Shi*. Structural characterization of PEGylated polyethylenimine-entrapped gold nanoparticles: An NMR study. Analyst 2016, 141, 5390 - 5397 (Impact factor 4.019, citation #10). 

13. Wenjie Sun#, Jia Yang#, Jianzhi Zhu, Yiwei Zhou, Jingchao Li, Xiaoyue Zhu, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Immobilization of Iron Oxide Nanoparticles within Alginate Nanogels for Enhanced MR Imaging Applications. Biomater. Sci. 2016, 4, 1422-1430 (impact factor 5.251, citation #14, front cover). 

14. Yong Hu#, Ruizhi Wang#, Shige Wang#, Ling Ding, Jingchao Li, Yu Luo, Xiaolin Wang,* Mingwu Shen*, Xiangyang Shi*. Multifunctional Fe3O4@Au Core/Shell Nanostars: A Unique Platform for Multimode Imaging and Photothermal Therapy of Tumors. Sci. Rep. 2016, 6, 28325 (impact factor 4.011, citation # 65). 

15. Xin Li#, Zuogang Xiong#, Xiaoying Xu, Yu Luo, Chen Peng*, Mingwu Shen*, and Xiangyang Shi*. 99mTc-Labeled Multifunctional Low Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT/CT Dual-Mode Imaging of Tumors. ACS Appl. Mater. Interfaces 2016, 8, 19883-19891 (impact factor 8.456, citation #30).

16. Wenjie Sun, Serge Mignani, Mingwu Shen*, Xiangyang Shi*. Dendrimer-based magnetic iron oxide nanoparticles: synthesis and biomedical applications. Drug Discov. Today 2016, 21 (12), 1873-1885 (Impact factor 6.880, citation #26). 

17. Yu Luo#, Lingzhou Zhao#, Xin Li, Jia Yang, Lilei Guo, Guixiang Zhang, Mingwu Shen*, Jinhua Zhao*, Xiangyang Shi*. The design of a multifunctional dendrimer-based nanoplatform for targeted dual mode SPECT/MR imaging of tumors. J. Mater. Chem. B 2016, 4, 7220-7225 (Impact factor 5.047, citation # 10). Ping Wei#, Jingwen Chen#, Yong Hu, Xin Li, Han Wang*, Mingwu Shen*, Xiangyang Shi*. Dendrimer-Stabilized Gold Nanostars as a Synergistic Theranostic Nanoplatform for CT Imaging, Photothermal Therapy and Gene Silencing of Tumors. Adv. Healthcare Mater. 2016, 5 (24), 3203-3213 (impact factor 6.270, citation #29). 

18. Yong Hu#, Ruizhi Wang#, Jingchao Li, Ling Ding, Xiaolin Wang,* Xiangyang Shi,* Mingwu Shen*. Facile Synthesis of Lactobionic Acid-Targeted Iron Oxide Nanoparticles with Ultrahigh Relaxivity for Targeted MR Imaging of an Orthotopic Model of Human Hepatocellular Carcinoma. Part. Part. Syst. Charact. 2017, 34, 1600113 (impact factor 4.194, citation #9). 

19. Peng Wang#, Jia Yang#, Benqing Zhou, Yong Hu, Lingxi Xing, Fanli Xu, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*. Antifouling manganese oxide nanoparticles: Synthesis, characterization, and applications for enhanced MR imaging of tumors. ACS Appl. Mater. Interfaces 2017, 9 (1), 47-53 (impact factor 8.456, citation #15).

20. Wenjie Sun#, Sabrina Thies#, Jiulong Zhang, Chen Peng*, Guangyu Tang, Mingwu Shen, Andrij Pich*, Xiangyang Shi*. Gadolinium-Loaded Poly(N-vinylcaprolactam) Nanogels: Synthesis, Characterization, and Application for Enhanced Tumor MR Imaging. ACS Appl. Mater. Interfaces 2017, 9 (4), 3411-3418 (impact factor 8.456, citation #23). 

21. Xin Li#, Lingxi Xing#, Kailiang Zheng, Ping Wei, Lingzhou Zhao, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. Formation of Gold Nanostar-Coated Hollow Mesoporous Silica for Tumor Multi-Modality Imaging and Photothermal Therapy. ACS Appl. Mater. Interfaces 2017, 9, 5817−5827 (impact factor 8.456, citation #59). 

22. Du Li#, Jia Yang#, Shihui Wen, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles. J. Mater. Chem. B 2017, 5, 2395- 2401 (Impact factor 5.047, citation # 8). 

23. Zhijuan Xiong#, Yue Wang#, Jingyi Zhu, Xin Li, Yao He, Jiao Qu, Mingwu Shen, Jindong Xia,* and Xiangyang Shi*. Dendrimers meet zwitterions: Development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging. Nanoscale 2017, 9, 12295-12301 (impact factor 6.970, citation #16). 

24. Yiwei Zhou, Yong Hu, Wenjie Sun, Benqing Zhou, Jianzhi Zhu, Chen Peng*, Mingwu Shen, Xiangyang Shi*. Polyaniline-Loaded γ-Polyglutamic Acid Nanogels as a Platform for Photoacoustic Imaging-Guided Tumor Photothermal Therapy. Nanoscale 2017, 9, 12746-12754 (impact factor 6.970, citation #16).

25. Xin Li#, Lingxi Xing#, Yong Hu, Zhijuan Xiong, Ruizhi Wang, Xiaoying Xu, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. An RGD-modified hollow silica@Au core/shell nanoplatform for tumor combinational therapy. Acta Biomater. 2017, 62, 273-283 (Impact factor 6.638, citation # 25). 

26. Jingchao Li, Shige Wang, Xiangyang Shi,* Mingwu Shen*. Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy. Adv. Colloid Interface Sci. 2017, 249, 374–385 (impact factor 8.243, citation #11). 

27. Feng Chen, Lingdan Kong, Le Wang, Yu Fan, Mingwu Shen*, Xiangyang Shi*. Construction of Core-shell Tecto Dendrimers Based on Supramolecular Host-Guest Assembly for Enhanced Gene Delivery. J. Mater. Chem. B 2017, 5, 8459--8466 (Impact factor 5.047, citation # 3, Front cover of the issue). 

28. Xiaoying Xu#, Lingzhou Zhao#, Xin Li, Peng Wang, Jinhua Zhao,* Xiangyang Shi*, Mingwu Shen*. Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles. Biomater. Sci. 2017, 5, 2393–2397 (impact factor 5.251, citation #14). 

29. Jingchao Li#, Hongdong Cai#, Shunyao Dong, Tianxiong Zhang, Chen Peng, Xiangyang Shi*, Mingwu Shen*.Facile Synthesis of Size- and Shape-Controlled Gd(OH)3 Nanoparticles and Gd(OH)3@Au Core/Shell Nanostars. New J. Chem. 2017, 41, 15136-15143 (impact factor 3.069, citation #0). 

30. Benqing Zhou, Zuogang Xiong, Peng Wang, Chen Peng*, Mingwu Shen*, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*.Targeted tumor dual mode CT/MR imaging using multifunctional polyethylenimine-entrapped gold nanoparticles loaded with gadolinium. Drug Delivery 2018, 25, 178-186 (Impact factor 3.829, citation #10).

31. Wenjie Sun#, Jiulong Zhang#, Changchang Zhang#, Peng Wang, Chen Peng,* Mingwu Shen* and Xiangyang Shi*. Construction of hybrid alginate nanogels loaded with manganese oxide nanoparticles for enhanced tumor MR imaging. ACS Macro Lett. 2018, 7, 137-142 (impact factor 5.775, citation #4). 

32. Benqing Zhou#, Ruizhi Wang#, Lingzhou Zhao, Peng Wang, Xin Li, István Bányai,* Qiang Ouyang*, Xiangyang Shi, and Mingwu Shen*. 99mTc-Labeled RGD−Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT/CT Imaging of Hepatic Carcinoma. ACS Appl. Mater. Interfaces 2018, 10 (7), 6146–6154 (impact factor 8.456, citation #8).

33. Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, and Xiangyang Shi*.Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev. 2018, 47, 1874-1900 (citation # 71, Impact factor 40.443).

34. Dengmai Hu, Yunchao Xiao, Hui Liu, Hong Wang, Jingchao Li, Benqing Zhou, Pengchao Liu*, Mingwu Shen*, Xiangyang Shi*. Loading of Au/Ag bimetallic nanoparticles within electrospun PVA/PEI nanofibers for catalytic applications. Colloid Surf. A-Physicochem. Eng. Aspects 2018, 552, 9-15 (citation #11, Impact factor 3.131).

35. Zheng Qiao, Mingwu Shen, Yunchao Xiao, Meifang Zhu, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*. Organic/inorganic nanohybrids formed using electrospun polymer nanofibers as nanoreactors. Coord. Chem. Rev. 2018, 372, 31-51 (impact factor 13.476, citation #5).

36. Yong Hu,# Ruizhi Wang,# Yiwei Zhou,# Nuo Yu, Zhigang Chen, Dongmei Gao,* Xiangyang Shi,* Mingwu Shen*. Targeted dual-mode imaging and phototherapy of tumors using ICG-loaded multifunctional MWCNTs as a versatile platform. J. Mater. Chem. B 2018, 6, 6122 - 6132 (Impact factor 5.047, citation # 5).

37. Jingyi Zhu#, Hongsheng Li#, Zhijuan Xiong, Mingwu Shen, Peter S. Conti, Xiangyang Shi*, Kai Chen*. Polyethyleneimine-coated manganese oxide nanoparticles for targeted tumor PET/MR imaging. ACS Appl. Mater. Interfaces 2018, 10(41), 34954-34964 (impact factor 8.456, citation #6).

38. Shiyi Lu, Xin Li, Jiulong Zhang, Chen Peng,* Mingwu Shen,* and Xiangyang Shi*. Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging-Guided Combination Therapy of Tumors. Adv. Sci. 2018, 5, 1801612 (citation #11, Impact factor 15.804).

39. Du Li, Shihui Wen, Wenjie Sun, Jiulong Zhang, Dayong Jin, Chen Peng*, Mingwu Shen*, Xiangyang Shi*. One-Step Loading of Gold and Gd2O3 Nanoparticles within PEGylated Polyethylenimine for Dual Mode CT/MR Imaging of Tumors. ACS Appl. Bio Mater. 2018, 1, 221–225.

40. Dan Li, Yu Fan, Mingwu Shen,* István Bányai*, Xiangyang Shi*. Design of dual drug-loaded dendrimer/carbon dot nanohybrids for fluorescence imaging and enhanced chemotherapy of cancer cells. J. Mater. Chem. B 2019, 7, 277-285 (Impact factor 5.047, citation #3).

41. Fuyin Zheng, Shige Wang, Wenxiu Hou, Pengchao Liu,* Xiangyang Shi,* Mingwu Shen*. Comparative study of resazurin reduction and MTT assays for cytocompatibility evaluation of nanofibrous materials. Anal. Methods 2019, 11, 483 - 489 (impact factor 2.378, citation #0).

42. Chao Cai, Xin Li, Yue Wang, Mengxue Liu, Xiangyang Shi*, Jindong Xia*, Mingwu Shen*. Polydopamine-Coated Gold Core/Hollow Mesoporous Silica Shell Particles as a Nanoplatform for Multimode Imaging and Photothermal Therapy of Tumors. Chem. Eng. J. 2019, 362, 842-850 (Impact factor 8.355, citation #2).

43. Jinyuan Liu, Zhijuan Xiong, Jiulong Zhang, Chen Peng*, Barbara Klajnert-Maculewicz*, Mingwu Shen*, Xiangyang Shi*. Zwitterionic Gadolinium (III)-Complexed Dendrimer-Entrapped Gold Nanoparticles for Enhanced Computed Tomography/Magnetic Resonance Imaging of Lung Cancer Metastasis. ACS Appl. Mater. Interfaces 2019, 11, 15212-15221 (impact factor 8.456, citation #1).

44. Xiaoying Xu, Kang Liu, Yue Wang, Changchang Zhang, Menghan Shi, Peng Wang, Linghong Shen, Jindong Xia,* Ling Ye,* Xiangyang Shi,* Mingwu Shen*. A Multifunctional Low-Generation Dendrimer-Based Nanoprobe for the Targeted Dual Mode MR/CT Imaging of Orthotopic Brain Gliomas. J. Mater. Chem. B 2019, 7, 3639-3643 (Impact factor 5.047, citation # 0).

45. Yili Zhao, Lei Liu, Daniel Shi, Xiangyang Shi,* Mingwu Shen*. Performing Catalysis Reaction on a Filter Paper: Development of Metal Palladium Nanoparticle-Based Catalyst. Nanoscale Adv. 2019, 1, 342-346.

46. Xin Li#, Shiyi Lu#, Zuogang Xiong, Yong Hu, Dan Ma, Wenqi Lou, Chen Peng*, Mingwu Shen*, Xiangyang Shi*. Light-Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis. Adv. Sci. 2019, 6, 1901800 (citation # 0, Impact factor 15.804).

47. Yu Zou#, Du Li#, Mingwu Shen,* and Xiangyang Shi*. Polyethylenimine-based nanogels for biomedical applications. Macromol. Biosci. 2019, 19, 1900272 (impact factor 2.895, citation # 1).

48. Wei Zhu, Lingzhou Zhao, Yu Fan, Jinhua Zhao*, Xiangyang Shi*, Mingwu Shen*. 131I-Labeled Multifunctional Polyphosphazene Nanospheres for SPECT Imaging-Guided Radiotherapy of Tumors. Adv. Healthcare Mater. 2019, 8, 1901299 (impact factor 6.270, citation #0).

49. Jianhong Wang, Du Li, Yu Fan, Menghan Shi, Yunxia Yang, Le Wang, Yitian Peng, Mingwu Shen,* Xiangyang Shi*. Core-Shell Tecto Dendrimers Formed via Host-Guest Supramolecular Assembly as a pH-Responsive Intelligent Carrier for Enhanced Anticancer Drug Delivery. Nanoscale 2019, 11, 22343–22350 (impact factor 6.970, citation #0).

50. Yili Zhao, Lei Liu, Daniel Shi, Xiangyang Shi,* Mingwu Shen*. Performing a Catalysis Reaction on Filter Paper: Development of a Metal Palladium Nanoparticle-Based Catalyst. Nanoscale Adv. 2019, 1, 342-346.

51. Lingxi Xing#, Xin Li#, Zehua Xing#, Fan Li, Mingwu Shen, Hong Wang*, Xiangyang Shi*, Lianfang Du*. Silica/Gold Nanoplatform combined with a Thermosensitive Gel for Imaging-guided Interventional Therapy in PDX of Pancreatic Cancer. Chem. Eng. J. 2020, 382, 122949 (Impact factor 8.355, citation #0).

52. Tingting Xiao, Du Li, Xiangyang Shi, Mingwu Shen*. PAMAM dendrimer-based nanodevices for nuclear medicine applications. Macromol. Biosci. 2020, 20, 1900282 (impact factor 2.895, citation # 0).

53. Changchang Zhang, Wenjie Sun, Yue Wang, Fang Xu, Jiao Qu, Jindong Xia, Mingwu Shen*, Xiangyang Shi*. Gd-/CuS-Loaded Functional Nanogels for MR/PA Imaging-Guided Tumor-Targeted Photothermal Therapy. ACS Appl. Mater. Interfaces 2020, 12, 9107-9117 (impact factor 8.456, citation #0).

54. 沈明武，李静超，胡勇，孙文杰，史向阳。一种叶酸修饰的超顺磁氧化铁纳米颗粒的制备方法。中国发明专利，专利号: ZL201410182821.1，授权日期：2016/8/24。

55. 沈明武，李静超，胡勇，韦平，史向阳。一种金包覆氧化铁星形核壳结构纳米颗粒的制备及其成像和热疗的应用。中国发明专利，专利号: ZL201410333885.7，授权日期：2016/11/9。

56. 沈明武，胡勇，李静超，韦平，史向阳。一种RGD修饰的超小型超顺磁氧化铁纳米颗粒的制备方法。中国发明专利，专利号：ZL201410604468.1，授权日期：2017/4/12。

57. 沈明武，韦平，胡勇，史向阳。一种RGD修饰树状大分子稳定的功能化金纳米星/siRNA复合物的制备方法。中国发明专利，申请号：201610018168.4，申请日期：2016.01.12。已授权，专利号：ZL201610018168.4，授权日期：2017/12/26。

58. 朱晓玥，徐刚伟，沈明武，尹迪，王梦媛，沈丹婕，史向阳。一种包埋功能化纳米纤维膜的微流控芯片及其应用。中国发明专利，申请号：201610415291.X，申请日期：2016.06.14。已授权，专利号：ZL201610415291.X，授权日期：2018/01/02。

59. 沈明武，胡勇，丁玲，史向阳，张贵祥，杨嘉。一种透明质酸修饰的超顺磁性氧化铁/金复合纳米探针的制备方法。中国发明专利，申请号：201410853396.4，申请日期：2014.12.31。已授权，专利号：ZL201410853396.4，授权日期：2018/05/15。

60. 沈明武，陆诗怡，李鑫，彭琛，史向阳。一种树状大分子稳定的超小四氧化三铁/金纳米花的制备方法。中国发明专利，申请号：201810282889.5，申请日期：2018-04-02。已授权，专利号：ZL201810282889.5，授权日期：2019/12/10。

    
    

国际交流与合作：

美国密歇根大学（University of Michigan, Ann Arbor），葡萄牙马德拉大学 (Universidade da Madeira)，匈牙利徳布勒森大学（University of Debrecen），德国亚琛工业大学（RWTH Aachen），韩国梨花女子大学，日本大阪大学。