史向阳教授
| 研究方向: 1.生物纳米技术：以各种基于树状大分子或生物相容性高分子修饰或组装的多种纳米 颗粒为医学平台，研究各种癌症的早期诊断和治疗。 2.新型纳米材料和纳米复合材料的合成、组装、表面修饰、性能、及其在生物医学中 的应用。 3.静电纺纳米纤维在生物医学和环境科学中的应用。
联系电话：021-67792656 EMAIL：xshi@dhu.edu.cn |
个人简介
史向阳，1970年8月生，现任化学化工与生物工程学院副院长，生物科学与技术研究所教授，博士生导师，校特聘教授，上海高校特聘教授（东方学者）。2008年回国前，在美国密歇根大学历任博士后研究员、第二级副研究员、研究员和研究助理教授。美国化学会、中国化学会、中国生物材料委员会会员，上海市生物物理学会理事，美国密歇根大学医学和生物科学纳米技术研究所客座研究员，首届葡萄牙马德拉大学“邀请纳米技术主任（Invited Chair in Nanotechnology）。是Current Nanoscience、American Journal of Nanotechnology、Advances in Nano Research, An International Journal、Journal of Modern Textile Science and Engineering等期刊编委，也是Nat. Nanotechnol.、Nat. Commun.和 J. Am. Chem. Soc.等84个国际杂志审稿人。
荣誉及获奖情况
2008 上海市教委“上海高校特聘教授（东方学者）”
2009 首批SCOPUS寻找未来科学之星活动纳米科学全国前10名
2009 获得上海市科委浦江人才计划
2010 首届由葡萄牙基金委（FCT）和Santander Totta银行赞助的“邀请纳米技术主任”称号
2011 教育部“新世纪优秀人才”
2013 上海市教委“上海高校特聘教授（东方学者）跟踪”
2014 第五届中国侨界贡献奖创新人才奖
2016 华夏医学科技奖二等奖
2017 上海市科技进步奖一等奖
2018 上海市自然科学奖一等奖
2018 上海领军人才
2019 上海市科委优秀学术带头人
主持与承担主要项目情况
智能型树状大分子纳米器件的设计及其增强肿瘤免疫治疗应用，上海市科委优秀学术带头人计划（19XD1400100），40万元，2019.5.1-2022.4.30，项目主持人。
Design of Copper Sulfide Nanoparticle-Loaded Functional Nanogels for Photoacoustic Imaging-Guided Tumor Photothermal Therapy/功能性纳米硫化铜负载的纳米凝胶的设计及其光声成像导引的肿瘤光热治疗，中德科学基金研究交流中心（The Sino-German Center for Research Promotion）合作研究小组项目，GZ1505，2019.01-2021.12，中方主持人，史向阳；德方主持人：Andrij Pich. 中方资助：916680元；德方资助：137386欧元（1084690万RMB），总经费200.1万元。
生物医用高分子，上海市教委上海领军人才（编号：ZX201903000002），160万元，2019.1.1-2021.12.31，项目主持人。
性离子修饰的树状大分子纳米平台的构筑及其乳腺癌诊疗应用，国家自然科学基金面上项目 (项目批准号：21773026)，65万元，2018.1-2021.12。项目主持人。
有机/无机纳米杂化平台的构建及其肿瘤精准成像与治疗，国家自然科学基金国际(地区)合作与交流项目，组织间合作研究—A3前瞻计划项目(中日韩)，（项目批准号：81761148028），400万元， 2017.8.1-2022.7.31，项目主持人。
具有抗污性能的树状大分子纳米器件的设计及其肿瘤精准诊疗应用，上海市科委政府间国际合作项目(17540712000)，50万元，2017.7.1-2020.6.30，项目主持人。
新型介孔氧化硅纳米粒的制备及其肿瘤诊疗应用，中央高校基本科研业务费专项资金学科交叉重点计划项目，40万元，2017.01-2019.12，项目主持人。
纳米载体体系的功能化及其药物传输和磁共振成像应用，科技部中国与匈牙利政府间科技合作项目(6-4)，2013.4-2015.4, 6万元，项目主持人。
负载抗癌药物的多功能树状大分子包裹的纳米金颗粒用于肿瘤的靶向CT诊断与治疗，教育部博士点基金（20130075110004），博导类，12万元，2014.01.01-2016.12.31，项目主持人。
上海市教委，上海高校特聘教授（东方学者）跟踪计划支持，100万元，2014.1-2016.12，项目主持人。
多功能杂化纳米水凝胶及其双模态分子影像学应用。中德科学基金研究交流中心，GZ899，2013.10-2016.9，中方主持人，史向阳；德方主持人：Andrij Pich.中方资助：718020元；德方资助：52240欧元，总经费113.7万元。
DENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors. Portuguese Fundação para a Ciência e a Tecnologia (FCT), PTDC/CTM-NAN/1748/2012, €197.616,00,2013.4.3-2015.4.2,项目主持人。
有机/无机纳米复合修复材料及其口腔医学应用开发。国家高技术研究发展计划(2012AA030309)；2012.1-2014.12，总经费864万元，下拨分卡经费30万元，项目主要学术骨干，排第四名。
利用树状大分子纳米技术构建多功能纳米杂化颗粒及其肿瘤CT/MRI双模态成像诊断研究。国家自然科学基金面上项目(项目批准号：21273032)，80万元，2013.1-2016.12。项目主持人。
树状大分子纳米材料及其医学应用，教育部新世纪人才支持计划，教育部(NCET-11-0618)，50万元，2012.1.1-2014.12.31，项目主持人。
多功能磁性氧化铁/金核壳纳米探针的构建及其分子影像诊断应用，上海市科委纳米专项（11nm0506400），40万元，2011.12.1-2014.9.30，项目主持人。
树状大分子纳米载药新体系的构建及其生物医学应用，东华大学中央高校基本科研业务费专项资金（追加），30万元，2011.10-2012.10，项目主持人。
多功能树状大分子作为纳米药物输送系统用于癌细胞的靶向治疗，教育部留学回国人员科研启动基金，2010.11.1-2012.10.31, 3万元，项目主持人。
功能化树状大分子与金属离子和小分子的相互作用及树状大分子类似物的合成（课题编号：5-14）,科技部中国与匈牙利政府间科技合作项目，2010.6.24-2012.6.30，中方项目主持人。
静电纺高分子纳米纤维反应器用于负载金属纳米颗粒及其催化剂应用研究。东华大学纤维材料改性国家重点实验室自主研究课题（课题编号：10M1060510），23万元，2010.9.1-2012.8.31，项目主持人。
多功能树状大分子包裹的纳米金颗粒作为平台用于癌细胞的CT成像研究。国家自然科学基金面上项目(项目批准号：20974019)，32万元，2010.1-2012.12。项目主持人。
项目名称：人工纳米生物机器构筑与生物医学应用的基础研究。课题名称：人工纳米生物机器的设计理论、模型与结构功能表征新方法的研究。973计划子课题（2007CB936000），40万元，2007.7.1-2011.8.31。排名第4，二级子课题负责人。
多功能树状大分子包裹的纳米金颗粒作为肿瘤CT成像造影剂的研究。上海市科委浦江人才计划（09PJ1400600），30万元，2009.7-2011.7。项目主持人。
基于树状大分子的纳米医学研究,上海市高校特聘教授（东方学者）奖励计划(8S10560)，50万，东华大学配套支持50万元，共100万，2008.6-2011.6,项目主持人。
东华大学校基金, 100万。项目主持人。
国际交流与合作
美国密歇根大学（University of Michigan, Ann Arbor），美国乔治亚大学格里芬分校（University of Georgia, Griffin），美国伊利诺伊大学芝加哥分校（University of Illinois at Chicago），葡萄牙马德拉大学 (Universidade da Madeira)，匈牙利徳布勒森大学（University of Debrecen），德国亚琛工业大学（RWTH Aachen），法国国家科学院（CNRS），韩国梨花女子大学，日本大阪大学。
主讲课程
纳米医学 (博士研究生课程)，化学前沿（博士研究生课程），纳米医学与生物技术（功能材料专业生物材料方向本科生课程）。
发表论著情况
史向阳教授的主要研究成果包括在纳米医学与生物技术、纳米科学、材料化学、高分子化学和分析化学等领域内共发表或接受发表了378篇SCI期刊论文，17篇书的章节，和303篇会议论文、摘要或报告，并获授权中国发明专利92项。文章总引用数超过15955次，H-index为71。研究工作发表在Chem. Rev., Chem. Soc. Rev., Prog. Polym. Sci., J. Am. Chem. Soc., Adv. Mater., Nano Lett., Adv. Funct. Mater., Adv. Sci., Small, Nano Today和Biomaterials等等专业杂志上。近5年(2015-2020)发表通讯作者SCI论文207篇，以通讯作者发表IF>7的论文49篇，获授权发明专利51项，出版专著章节11章。
2015年以来发表的代表论著
1. Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen*, Guixiang Zhang,* Xiangyang Shi*. Hyaluronic Acid-Modified Fe3O4@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials 2015, 38, 10-21 (impact factor 10.317, citation #213, ESI061116).
2. Yong Hu, Jingchao Li, Jia Yang, Ping Wei, Yu Luo, Ling Ding, Wenjie Sun, Guixiang Zhang*, Xiangyang Shi*, Mingwu Shen*. Facile synthesis of RGD peptide-modified iron oxide nanoparticles with ultrahigh relaxivity for targeted MR imaging of tumors. Biomater. Sci.2015, 3, 721-732 (impact factor 6.183, citation #40).
3. Yu Luo, Jia Yang, Yu Yan, Jingchao Li, Mingwu Shen*, Guixiang Zhang,* Serge Mignani, Xiangyang Shi*. RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T1-weighted MR imaging of glioma. Nanoscale 2015, 7, 14538–14546 (impact factor 6.895, citation #55).
4. Lingdan Kong, Carla S. Alves, Wenxiu Hou, Jieru Qiu, Helmuth Möhwald, Helena Tomás,* Xiangyang Shi*. RGD Peptide-Modified Dendrimer-Entrapped Gold Nanoparticles Enable Highly Efficient and Specific Gene Delivery to Stem Cells. ACS Appl. Mater. Interfaces 2015, 7 (8), 4833-4843 (impact factor 8.758, citation #76, ESI paper).
5. Jia Yang, Yu Luo, Yanhong Xu, Jingchao Li, Zaixian Zhang, Han Wang, Mingwu Shen, Xiangyang Shi,* Guixiang Zhang*. Conjugation of iron oxide nanoparticles with RGD-modified dendrimers for targeted tumor MR imaging. ACS Appl. Mater. Interfaces 2015, 7(9), 5420-5428 (impact factor 8.758, citation #42).
6. Yu Luo, He Shen, Yongxiang Fang, Yuhua Cao, Jie Huang, Mengxin Zhang, Jianwu Dai,* Xiangyang Shi,* and Zhijun Zhang*. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl. Mater. Interfaces2015, 7 (11), 6331–6339 (impact factor 8.758, citation #160).
7. Qian Chen, Han Wang, Hui Liu, Shihui Wen, Chen Peng, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Multifunctional Dendrimer-Entrapped Gold Nanoparticles Modified with RGD Peptide for Targeted Computed Tomography/Magnetic Resonance Dual-Modal Imaging of Tumors. Anal. Chem. 2015, 87 (7), pp 3949–3956 (Impact factor 6.785, citation #78).
8. Zheng Qiao, Xiangyang Shi*. Dendrimer-based molecular imaging contrast agents. Prog. Polym. Sci. 2015, 44, 1–27 (Impact factor 22.620, citation #83).
9. Chen Shao, Shuai Li, Wei Gu, Ningqiang Gong, Juan Zhang, Ning Chen, Xiangyang Shi,* Ling Ye*. Multifunctional Gadolinium-Doped Manganese Carbonate Nanoparticles for Targeted MR/Fluorescence Imaging of Tiny Brain Gliomas. Anal. Chem. 2015, 87 (12), 6251–6257 (Impact factor 6.785, citation #17).
10. Yulin Li*, Dina Maciel, João Rodrigues*, Xiangyang Shi*, Helena Tomás*. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chem. Rev.2015,115 (16), 8564–8608 (impact factor 52.758, citation #197).
11. Du Li, Shihui Wen, Xiangyang Shi*. Dendrimer-entrapped metal colloids as imaging agents. Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol.2015, 7, 678–690 (impact factor 7.689, invited, citation #15).
12. Lingzhou Zhao, Jingyi Zhu, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Lilei Guo, Xiangyang Shi*, and Jinhua Zhao*. Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide 131I for SPECT Imaging and Radiotherapy of Gliomas. ACS Appl. Mater. Interfaces 2015, 7 (35), 19798–19808 (impact factor 8.758, citation #44).
13. Hongdong Cai#, Kangan Li#, Jingchao Li, Shihui Wen, Qian Chen, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Dendrimer-Assisted Formation of Fe3O4/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors. Small2015, 11 (35), 4584-4593 (impact factor 11.459, citation #79).
14. Yongxing Zhang#, Shihui Wen#, Lingzhou Zhao#, Du Li#, Changcun Liu, Wenbin Jiang, Xiang Gao, Wentao Gu, Nan Ma, Jinhua Zhao*, Xiangyang Shi*, Qinghua Zhao*. Ultrastable polyethyleneimine-stabilized gold nanoparticles modified with polyethylene glycol for blood pool, lymph node and tumor CT imaging. Nanoscale 2016, 8, 5567–5577 (impact factor 6.895, citation #19).
15. Ling Ding#, Yong Hu#, Yu Luo, Jianzhi Zhu, Yilun Wu, Zhibo Yu, Xueyan Cao, Chen Peng,* Xiangyang Shi,* Rui Guo*. Laponite-stabilized iron oxide nanoparticles for in vivo MR imaging of tumors. Biomater. Sci. 2016,4, 474-482(impact factor 6.183, citation #17).
16. Jingwen Chen#, Yingqi Sun#, Qian Chen#, Le Wang, Suhe Wang, Yun Tang,* Xiangyang Shi*, Han Wang*. Multifunctional gold nanocomposites designed for targeted CT/MR/optical tri-modal imaging of human non-small cell lung cancer cells. Nanoscale 2016, 8, 13568–13573 (impact factor 6.895, citation #11).
17. Wenjie Sun#, Jia Yang#, Jianzhi Zhu, Yiwei Zhou, Jingchao Li, Xiaoyue Zhu, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Immobilization of Iron Oxide Nanoparticles within Alginate Nanogels for Enhanced MR Imaging Applications. Biomater. Sci. 2016,4, 1422-1430 (impact factor 6.183, citation #18, front cover).
18. Zhijuan Xiong#, Yue Wang#, Jingyi Zhu, Yao He, Jiao Qu, Christiane Effenberg, Jindong Xia,* Dietmar Appelhans,* Xiangyang Shi*. Gd-Chelated Poly(propylene imine) Dendrimers with Densely Organized Maltose Shells for Enhanced MR Imaging Applications. Biomater. Sci. 2016, 4, 1622-1629 (impact factor 6.183, citation #12).
19. Xin Li#, Zuogang Xiong#, Xiaoying Xu, Yu Luo, Chen Peng*, Mingwu Shen*, and Xiangyang Shi*. 99mTc-Labeled Multifunctional Low Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT/CT Dual-Mode Imaging of Tumors. ACS Appl. Mater. Interfaces 2016, 8, 19883-19891 (impact factor 8.758, citation #36).
20. Aijun Li, Benqing Zhou, Carla S. Alves, Bei Xu, Rui Guo, Xiangyang Shi,* Xueyan Cao*. Mechanistic Studies of the Enhanced PCR Using PEGylated PEI-Entrapped Gold Nanoparticles. ACS Appl. Mater. Interfaces2016, 8 (39), 25808–25817 (impact factor 8.758, citation #12).
21. Wenjie Sun, Serge Mignani, Mingwu Shen*, Xiangyang Shi*. Dendrimer-based magnetic iron oxide nanoparticles: synthesis and biomedical applications. Drug Discov. Today2016, 21 (12), 1873-1885 (Impact factor 7.321, citation #30).
22. Ping Wei#, Jingwen Chen#, Yong Hu, Xin Li, Han Wang*, Mingwu Shen*, Xiangyang Shi*. Dendrimer-Stabilized Gold Nanostars as a Synergistic Theranostic Nanoplatform for CT Imaging, Photothermal Therapy and Gene Silencing of Tumors. Adv. Healthcare Mater. 2016, 5 (24), 3203-3213 (impact factor 7.367, citation #36).
23. Peng Wang#, Jia Yang#, Benqing Zhou, Yong Hu, Lingxi Xing, Fanli Xu, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*. Antifouling manganese oxide nanoparticles: Synthesis, characterization, and applications for enhanced MR imaging of tumors. ACS Appl. Mater. Interfaces 2017, 9 (1), 47-53 (impact factor 8.758, citation #19).
24. Wenjie Sun#, Sabrina Thies#, Jiulong Zhang, Chen Peng*, Guangyu Tang, Mingwu Shen, Andrij Pich*, Xiangyang Shi*. Gadolinium-Loaded Poly(N-vinylcaprolactam) Nanogels: Synthesis, Characterization, and Application for Enhanced Tumor MR Imaging. ACS Appl. Mater. Interfaces 2017, 9 (4), 3411-3418 (impact factor 8.758, citation #28).
25. Lingdan Kong, Jieru Qiu, Wenjie Sun, Jia Yang, Mingwu Shen, Xiangyang Shi*. Multifunctional PEI-entrapped gold nanoparticles enable efficient delivery of therapeutic siRNA into glioblastoma cells. Biomater. Sci. 2017, 5, 258-266(impact factor 6.183, citation #24).
26. Xin Li#, Lingxi Xing#, Kailiang Zheng, Ping Wei, Lingzhou Zhao, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. Formation of Gold Nanostar-Coated Hollow Mesoporous Silica for Tumor Multi-Modality Imaging and Photothermal Therapy. ACS Appl. Mater. Interfaces 2017, 9, 5817−5827 (impact factor 8.758, citation #66).
27. Gangwei Xu, Yulong Tan, Tiegang Xu, Di Yin, Mengyuan Wang, Mingwu Shen, Xiaofeng Cheng,* Xiangyang Shi,* Xiaoyue Zhu*. Hyaluronic Acid-Functionalized Electrospun PLGA Nanofibers Embedded in a Microfluidic chip for Cancer Cell Capture and Culture. Biomater. Sci. 2017, 5, 752–761 (impact factor 6.183, citation #23).
28. Lingdan Kong#, Lingxi Xing#, Benqing Zhou, Lianfang Du*, Xiangyang Shi*. Dendrimer-Modified MoS2 Nanoflakes as a Platform for Combinational Gene Silencing and Photothermal Therapy of Tumors. ACS Appl. Mater. Interfaces 2017, 9 (19), 15995–16005 (impact factor 8.758, citation #41).
29. Nuo Yu#, Yong Hu#, Gang Liu, Xiaoyong Wang, Zhaojie Wang, Zixiao Liu, Meifang Zhu, Xiangyang Shi*, Zhigang Chen*. Dynamically Tuning Near-infrared-induced Photothermal Performances of TiO2 Nanocrystals by Nb-doping for Imaging Guided Photothermal Therapy of Tumors. Nanoscale 2017, 9, 9148–9159 (impact factor 6.895, citation #28).
30. Yunan Wang, Wenwen Shen, Xiangyang Shi, Fanfan Fu, Yini Cao, Qiang Zhang, Rong Qi*. Alpha-Tocopheryl Succinate-Conjugated Dendrimer Enables Effective Inhibition of Ulcerative Colitis. Adv. Healthcare Mater. 2017, 6, 1700276(impact factor 7.367, citation #7).
31. Zhijuan Xiong#, Yue Wang#, Jingyi Zhu, Xin Li, Yao He, Jiao Qu, Mingwu Shen, Jindong Xia,* and Xiangyang Shi*. Dendrimers meet zwitterions: Development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging. Nanoscale 2017, 9, 12295-12301 (impact factor 6.895, citation #20).
32. Yiwei Zhou, Yong Hu, Wenjie Sun, Benqing Zhou, Jianzhi Zhu, Chen Peng*, Mingwu Shen, Xiangyang Shi*. Polyaniline-Loaded γ-Polyglutamic Acid Nanogels as a Platform for Photoacoustic Imaging-Guided Tumor Photothermal Therapy. Nanoscale 2017, 9, 12746-12754 (impact factor 6.895, citation #21).
33. Xin Li#, Lingxi Xing#, Yong Hu, Zhijuan Xiong, Ruizhi Wang, Xiaoying Xu, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. An RGD-modified hollow silica@Au core/shell nanoplatform for tumor combinational therapy. Acta Biomater. 2017, 62, 273-283 (Impact factor 7.242, citation # 27).
34. Jingchao Li, Shige Wang, Xiangyang Shi,* Mingwu Shen*. Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy. Adv. Colloid Interface Sci. 2017, 249, 374–385 (impact factor 9.922, citation #14).
35. Yu Fan#, Wenjie Sun#, Xiangyang Shi*. Design and Biomedical Applications of Poly(amidoamine) Dendrimer-Based Hybrid Nanoarchitectures. Small Methods 2017, 1(12), 1700224 (impact factor 12.130, citation #13).
36. Lizhou Lin#, Yu Fan#, Feng Gao, Lifang Jin, Dan Li, Wenjie Sun,Fan Li, Peng Qin, Qiusheng Shi*, Xiangyang Shi*, Lianfang Du*.UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy. Theranostics2018, 8(7), 1923-1939 (impact factor 8.579, citation #24).
37. Serge Mignani*, João Rodrigues*, Helena Tomas, Maria Zablocka, Xiangyang Shi, Anne-Marie Caminade, Jean-Pierre Majoral*. Dendrimers in combination with natural products and analogues as anti-cancer agents. Chem. Soc. Rev. 2018, 47, 514-532 (citation # 41, Impact factor 42.846).
38. Wenjie Sun#, Jiulong Zhang#, Changchang Zhang#, Peng Wang, Chen Peng,* Mingwu Shen* and Xiangyang Shi*. Construction of hybrid alginate nanogels loaded with manganese oxide nanoparticles for enhanced tumor MR imaging. ACS Macro Lett. 2018, 7, 137-142 (impact factor 6.042, citation #6).
39. Benqing Zhou#, Ruizhi Wang#, Lingzhou Zhao, Peng Wang, Xin Li, István Bányai,* Qiang Ouyang*, Xiangyang Shi, and Mingwu Shen*. 99mTc-Labeled RGD−Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT/CT Imaging of Hepatic Carcinoma. ACS Appl. Mater. Interfaces 2018, 10 (7), 6146–6154 (impact factor 8.758, citation #11).
40. Jean-Pierre Majoral*,Maria Zablocka*, Anne-Marie Caminade, Piotr Balczewski,Xiangyang Shi, Serge Mignani*. Interactions gold/phosphorus dendrimers. Versatile ways to hybrid organic-metallic macromolecules.Coord. Chem. Rev. 2018, 358, 80-91 (impact factor 15.367, citation #7).
41. Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, and Xiangyang Shi*. Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev. 2018, 47, 1874-1900 (citation # 89, Impact factor 42.846).
42. Yunchao Xiao, Mengyuan Wang, Lizhou Lin, Lianfang Du, Mingwu Shen, Xiangyang Shi*. Integration of aligned polymer nanofibers within a microfluidic chip for efficient capture and rapid release of circulating tumor cells. Mater. Chem. Front. 2018, 2, 891-900 (impact factor 6.788, citation #10).
43. Yiwei Zhou, Yong Hu, Wenjie Sun, Shiyi Lu, Chao Cai, Chen Peng*, Jing Yu, Rachela Popovtzer*, Mingwu Shen, Xiangyang Shi*. Radiotherapy-Sensitized Tumor Photothermal Ablation Using γ-Polyglutamic Acid Nanogels Loaded with Polypyrrole. Biomacromolecules 2018, 19 (6), 2034–2042 (Impact factor 6.092, citation # 14).
44. Zheng Qiao, Mingwu Shen, Yunchao Xiao, Meifang Zhu, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*. Organic/inorganic nanohybrids formed using electrospun polymer nanofibers as nanoreactors.Coord. Chem. Rev. 2018, 372, 31-51 (impact factor 15.367, citation #5).
45. Jingyi Zhu#, Hongsheng Li#, Zhijuan Xiong, Mingwu Shen, Peter S. Conti, Xiangyang Shi*, Kai Chen*. Polyethyleneimine-coated manganese oxide nanoparticles for targeted tumor PET/MR imaging. ACS Appl. Mater. Interfaces 2018, 10(41), 34954-34964 (impact factor 8.758, citation #14).
46. Serge Mignani*, João Rodrigues, Helena Tomas, René Roy, Xiangyang Shi, Jean-Pierre Majoral*. Bench-to-bedside translation of dendrimers: Reality or utopia? A concise analysis. Adv. Drug Deliver. Rev. 2018, 136–137, 73–81 (impact factor 13.300, citation # 12).
47. Jean-Pierre Majoral, Xiangyang Shi, Serge Mignani. New opportunities of dendrimers for theranostic approaches to personalized medicine. Sci. China Mater. 2018, 61, 1365-1366 (Impact factor 6.098, citation # 0).
48. Serge Mignani*, Joao Rodrigues*, Helena Tomas, Anne-Marie Caminade, Régis Laurent, Xiangyang Shi*, Jean-Pierre Majoral*. Recent Therapeutic Applications of the Theranostic Principle with Dendrimers in Oncology.Sci. China Mater. 2018, 61, 1367–1386 (Impact factor 6.098, citation # 3).
49. Zhijuan Xiong, Mingwu Shen, Xiangyang Shi*. Dendrimer-based strategies for cancer therapy: Recent advances and future perspectives. Sci. China Mater. 2018, 61, 1387–1403(impact factor 6.098, citation #8).
50. Shiyi Lu, Xin Li, Jiulong Zhang, Chen Peng,* Mingwu Shen,* and Xiangyang Shi*. Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging-Guided Combination Therapy of Tumors. Adv. Sci. 2018, 5, 1801612 (citation #19, Impact factor 15.840).
51. Wenhui Ma#, Fanfan Fu#, Jingyi Zhu, Rui Huang, Yizhou Zhu, Zhenwei Liu, Jing Wang, Peter S. Conti, Xiangyang Shi*, Kai Chen*. 64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging. Nanoscale 2018, 10, 6113–6124 (impact factor 6.895, citation #11).
52. Du Li, Shihui Wen, Wenjie Sun, Jiulong Zhang, Dayong Jin, Chen Peng*, Mingwu Shen*, Xiangyang Shi*. One-Step Loading of Gold and Gd2O3 Nanoparticles within PEGylated Polyethylenimine for Dual Mode CT/MR Imaging of Tumors. ACS Appl. Bio Mater.2018, 1, 221–225.
53. Jianzhi Zhu#, Zhicong Li#, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi*, Han Wang*, Jan C. M. van Hest*. Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy. Theranostics 2019, 9(26), 8048-8060 (impact factor 8.579, citation #0).
54. Yu Fan, Jiulong Zhang, Menghan Shi, Dan Li, Chunhua Lu, Xueyan Cao, Chen Peng*, Serge Mignani*, Jean-Pierre Majoral*, Xiangyang Shi*. PAMAM Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for Radiotherapy-Enhanced MR Imaging and Chemotherapy of Tumors and Tumor Metastasis. Nano Lett. 2019, 19, 1216−1226(citation # 6, Impact factor 11.238).
55. Cong Song, Wenjie Sun, Yunchao Xiao, Xiangyang Shi*. Ultrasmall iron oxide nanoparticles: synthesis, surface modification, assembly and biomedical applications. Drug Discov. Today2019, 24(3), 825-844 (Impact factor 7.321, citation #8).
56. Chao Cai, Xin Li, Yue Wang, Mengxue Liu, Xiangyang Shi*, Jindong Xia*, Mingwu Shen*. Polydopamine-Coated Gold Core/Hollow Mesoporous Silica Shell Particles as a Nanoplatform for Multimode Imaging and Photothermal Therapy of Tumors. Chem. Eng. J. 2019, 362, 842-850 (Impact factor 10.652, citation #9).
57. Jinyuan Liu, Zhijuan Xiong, Jiulong Zhang, Chen Peng*, Barbara Klajnert-Maculewicz*, Mingwu Shen*, Xiangyang Shi*.Zwitterionic Gadolinium (III)-Complexed Dendrimer-Entrapped Gold Nanoparticles for Enhanced Computed Tomography/Magnetic Resonance Imaging of Lung Cancer Metastasis. ACS Appl. Mater. Interfaces 2019, 11, 15212-15221 (impact factor 8.758, citation #8).
58. Serge Mignani*, João Rodrigues*, René Roy, Xiangyang Shi, Valentin Ceña, Saïd El Kazzouli, Jean-Pierre Majoral. Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: Key factor analysis (Part 1). Drug Discov. Today 2019, 24(5), 1176-1183 (Impact factor 7.321, citation #3).
59. Serge Mignani*, João Rodrigues*, René Roy, Xiangyang Shi, Valentin Ceña, Saïd El Kazzouli, Jean-Pierre Majoral*. Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: Key factor analysis (Part 2). Drug Discov. Today 2019, 24(5), 1184-1192 (Impact factor 7.321, citation #4).
60. Xin Li#, Shiyi Lu#, Zuogang Xiong, Yong Hu, Dan Ma, Wenqi Lou, Chen Peng*, Mingwu Shen*, Xiangyang Shi*. Light-Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis. Adv. Sci. 2019, 6, 1901800 (citation # 3, Impact factor 15.840).
61. Aijun Li#, Yu Fan#, Xueyan Cao#, Liang Chen, Le Wang, Carla S. Alves, Serge Mignani, Jean-Pierre Majoral,* Helena Tomás,* and Xiangyang Shi*. Morpholino-functionalized phosphorus dendrimers for personalized regenerative medicine: Osteogenic differentiation of mesenchymal stem cells. Nanoscale 2019, 11, 17230-17234 (impact factor 6.895, citation #0).
62. Changchang Zhang#, Elisabeth Gau#, Wenjie Sun, Jianzhi Zhu, Ben Michael Schmidt, Andrij Pich*, and Xiangyang Shi*. Influence of Size, Crosslinking Degree and Surface Structure of Poly(N-vinylcaprolactam)-Based Microgels on Their Penetration into Multicellular Tumor Spheroids. Biomater. Sci. 2019, 7, 4738 - 4747 (Impact factor 6.183, citation #0).
63. Zhijuan Xiong, Carla S. Alves, Jianhua Wang, Aijun Li, Jinyuan Liu, Feng Chen, Mingwu Shen, João Rodrigues, Helena Tomás, Xiangyang Shi*. Zwitterion-Functionalized Dendrimer-Entrapped Gold Nanoparticles for Serum-Enhanced Gene Delivery to Inhibit Cancer Cell Metastasis. Acta Biomater. 2019, 99, 320-329 (Impact factor 7.242, citation # 0).
64. Wei Zhu, Lingzhou Zhao, Yu Fan, Jinhua Zhao*, Xiangyang Shi*, Mingwu Shen*. 131I-Labeled Multifunctional Polyphosphazene Nanospheres for SPECT Imaging-Guided Radiotherapy of Tumors. Adv. Healthcare Mater. 2019, 8, 1901299 (impact factor 7.367, citation #0).
65. Jianhong Wang, Du Li, Yu Fan, Menghan Shi, Yunxia Yang, Le Wang, Yitian Peng, Mingwu Shen,* Xiangyang Shi*. Core-Shell Tecto Dendrimers Formed via Host-Guest Supramolecular Assembly as a pH-Responsive Intelligent Carrier for Enhanced Anticancer Drug Delivery. Nanoscale 2019, 11, 22343–22350 (impact factor 6.895, citation #0).
66. Xinxin Hao, Bei Xu, Huan Chen, Xiaomeng Wang, Jiulong Zhang, Rui Guo, Xiangyang Shi* and Xueyan Cao*. Stem Cell-Mediated Delivery of Nanogels Loaded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Tumor MR Imaging. Nanoscale 2019, 11, 4904–4910 (impact factor 6.895, citation #4).
67. Lingxi Xing#, Xin Li#, Zehua Xing#, Fan Li, Mingwu Shen, Hong Wang*, Xiangyang Shi*, Lianfang Du*. Silica/Gold Nanoplatform combined with a Thermosensitive Gel for Imaging-guided Interventional Therapy in PDX of Pancreatic Cancer. Chem. Eng. J. 2020, 382, 122949 (Impact factor 10.652, citation #0).
68. Jennifer Daeg, Xiaoying Xu, Lingzhao Zhao, Susanne Boye, Andreas Janke, Achim Temme, Jinhua Zhao, Albena Lederer, Brigitte Voit,* Xiangyang Shi*, Dietmar Appelhans*. Bivalent Peptide- and Chelator-ContainingBioconjugates as Toolbox Components for Personalized Nanomedicine. Biomacromolecules2020, 21, 199-213 (Impact factor 6.092, citation #0).
69. Ni Zhang, Yue Wang, Changchang Zhang, Yu Fan, Du Li, Xueyan Cao, Jindong Xia, Xiangyang Shi, Rui Guo*. LDH-Stabilized Ultrasmall Iron Oxide Nanoparticles as a Platform for Hyaluronidase-Promoted MR Imaging and Chemotherapy of Tumors. Theranostics 2020, 10, 2791-2802 (impact factor 8.579, citation #0).
70. Changchang Zhang, Wenjie Sun, Yue Wang, Fang Xu, Jiao Qu, Jindong Xia, Mingwu Shen*, Xiangyang Shi*. Gd-/CuS-Loaded Functional Nanogels for MR/PA Imaging-Guided Tumor-Targeted Photothermal Therapy. ACS Appl. Mater. Interfaces 2020, 12, 9107-9117 (impact factor 8.758, citation #0).
71. Fang Xu#, Jianzhi Zhu#, Lizhou Lin#, Changchang Zhang, Wenjie Sun, Yu Fan, Fangfang Yin, Jan C. M. van Hest, Han Wang, Lianfang Du* and Xiangyang Shi*. Redox-responsive PVCL nanogels loaded with MnO2 nanoparticles and doxorubicin for imaging-guided and UTMD-promoted chemotherapy of tumors. Theranostics 2020, 10(10), 4349-4358 (impact factor 8.579, citation #0).
72. Ningning Song, Lingzhou Zhao, Xiaoying Xu, Meilin Zhu, Changcun Liu, Na Sun, Jiqin Yang,* Xiangyang Shi,* Jinhua Zhao*. LyP-1-modified multifunctional dendrimers for targeted anti-tumor and anti-metastasis therapy. ACS Appl. Mater. Interfaces 2020, 12, 12395-12406 (impact factor 8.758, citation #0).
73. Yu Fan#, Wenzhi Tu#, Mingwu Shen, Xuming Chen, Yuesheng Ning, Junjun Li, Tingfeng Chen, Han Wang, Fangfang Yin, Yong Liu*, Xiangyang Shi*. Targeted Tumor Hypoxia Dual Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer-Based Nanosensitizers. Adv. Funct. Mater. 2020, 30, 1909285 (impact factor 16.836, citation #0).
74. Meixiu Chen, Oshra Betzer, Yu Fan, Yue Gao, Mingwu Shen, Tamar Sadan, Rachela Popovtzer,* Xiangyang Shi*. Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Labelling and Tracking T Cells via Dual-Modal CT and Fluorescence Imaging. Biomacromolecules 2020, 21, 1587-1595 (Impact factor 6.092, citation #0).
75. Liang Chen#, Jin Li#, Yu Fan, Jieru Qiu, Liu Cao, Régis Laurent, Serge Mignani*, Anne-Marie Caminade, Jean-Pierre Majoral* and Xiangyang Shi*. Revisiting Cationic Phosphorus Dendrimers as a Nonviral Vector for Optimized Gene Delivery Toward Cancer Therapy Applications. Biomacromolecules 2020, 21, 2502-2511 (Impact factor 6.092, citation #0).
76. Serge Mignani*, Xangyang Shi*, Valentin Ceña, Jean-Pierre Majoral*. Dendrimer- and polymeric nanoparticle-aptamer bioconjugates as non-viral delivery systems: a new approach in nanomedicine. Drug Discov. Today 2020, 25, 1065-1073. DOI: 10.1016/j.drudis.2020.03.009 (Impact factor 7.321, citation #0).
77. Cong Song, Mingwu Shen, João Rodrigues, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*.Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: a concise review. Coord. Chem. Rev. 2020, 421, 213463. DOI: 10.1016/j.ccr.2020.213463 (impact factor 15.367, citation #0).
78. Yu Fan, Lizhou Lin, Fangfang Yin, Yu Zhu, Han Wang, Lianfang Du, Serge Mignani, Jean-Pierre Majoral*, Xiangyang Shi*. Phosphorus Dendrimer-Based Copper(II) Complexes Enable Ultrasound-Enhanced Tumor Theranostics. Nano Today 2020, DOI: 10.1016/j.nantod.2020.100899 (impact factor 16.907, citation #0).
79. Jingchao Li, Xiaoying Wang, Mingwu Shen,* and Xiangyang Shi*. Polyethylenimine-Assisted Generation of Optical Nanoprobes for Biosensing Applications. ACS Appl. Bio Mater. 2020, DOI:10.1021/acsabm.0c00536.
博士后和研究生招生信息
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