研究方向: 1、高分子纳米药物输送体系的制备与抗肿瘤效果评价。 2、有机/无机纳米复合材料的合成及其在肿瘤诊断中的应用。 3、静电纺纳米纤维材料在生物医学与环境科学中的应用。 联系电话:021-67792750 EMAIL:ruiguo@dhu.edu.cn |
个人简介:
郭睿,1980年生。2008年6月毕业于南京大学,获高分子化学与物理博士学位,现为东华大学化学化工与生物工程学院副研究员。目前承担《高分子化学与物理》的本科生教学任务,以及《纳米医学》《胶体与界面化学》研究生课程的教学工作。目前主持国家自然科学基金、上海市自然科学基金等项目,完成东华大学校基金、中央高校基金、纺织面料教育部重点实验室基金等科研项目,参与了多项国家自然科学基金、国家“973”计划以及上海市科研项目。已在相关领域发表SCI论文六十余篇。
承担的研究项目:
基于超分子主客体组装构建的核-壳结构树状大分子纳米平台用于肿瘤靶向的多模态成像与协同治疗,国家自然科学基金,2019.01-2022.12,项目负责人。
锂皂石-聚多巴胺杂化纳米载体的设计及其肿瘤靶向诊疗研究,上海市自然科学基金,2017.05-2020.04,项目负责人。
基于纳米锂皂石的药物输送体系用于乳腺癌的靶向化疗,国家自然科学基金青年基金,2013.01-2015.12,项目负责人。
近五年代表性论文:
T. Jiang, G. Chen, X. Shi and R. Guo, Hyaluronic Acid-Decorated Laponite((R)) Nanocomposites for Targeted Anticancer Drug Delivery, Polymers, 2019, 11.
F. L. Xu, M. X. Liu, X. Li, Z. J. Xiong, X. Y. Cao, X. Y. Shi and R. Guo, Loading of Indocyanine Green within Polydopamine-Coated Laponite Nanodisks for Targeted Cancer Photothermal and Photodynamic Therapy, Nanomaterials, 2018, 8, 16.
Y. Zhuang, L. Z. Zhou, L. F. Zheng, Y. Hu, L. Ding, X. Li, C. C. Liu, J. H. Zhao, X. Y. Shi and R. Guo, LAPONITE-Polyethylenimine Based Theranostic Nanoplatform for Tumor-Targeting CT Imaging and Chemotherapy, Acs Biomaterials Science & Engineering, 2017, 3, 431-442.
Y. Fan, R. Guo, X. Shi, S. Allen, Z. Cao, J. R. Baker and S. H. Wang, Modified Nanoemulsions with Iron Oxide for Magnetic Resonance Imaging, Nanomaterials, 2016, 6.
L. Ding, Y. Hu, Y. Luo, J. Zhu, Y. Wu, Z. Yu, X. Cao, C. Peng, X. Shi and R. Guo, LAPONITE (R)-stabilized iron oxide nanoparticles for in vivo MR imaging of tumors, Biomaterials Science, 2016, 4, 474-482.
R. Mustafa, Y. Luo, Y. Wu, R. Guo and X. Shi, Dendrimer-Functionalized Laponite Nanodisks as a Platform for Anticancer Drug Delivery, Nanomaterials, 2015, 5, 1716-1731.
W. Hou, S. Wen, R. Guo, S. Wang and X. Shi, Partially Acetylated Dendrimer-Entrapped Gold Nanoparticles with Reduced Cytotoxicity for Gene Delivery Applications, Journal of Nanoscience and Nanotechnology, 2015, 15, 4094-4105.
G. Chen, D. Li, J. Li, X. Cao, J. Wang, X. Shi and R. Guo, Targeted doxorubicin delivery to hepatocarcinoma cells by lactobionic acid-modified laponite nanodisks, New Journal of Chemistry, 2015, 39, 2847-2855.
M. Zhang, R. Guo, M. Keri, I. Banyai, Y. Zheng, M. Cao, X. Cao and X. Shi, Impact of Dendrimer Surface Functional Groups on the Release of Doxorubicin from Dendrimer Carriers, Journal of Physical Chemistry B, 2014, 118, 1696-1706.
R. Qi, R. Guo, F. Zheng, H. Liu, J. Yu and X. Shi, Controlled release and antibacterial activity of antibiotic-loaded electrospun halloysite/poly(lactic-co-glycolic acid) composite nanofibers, Colloids and Surfaces B-Biointerfaces, 2013, 110, 148-155.
|