 | Mingwu Shen, Ph. 2999 North Renmin Road College of Chemistry, Chemical Engineering, and Biotechnology Donghua University Shanghai 201620, China. Phone: 021-67792750 E-mail: mwshen@dhu.edu.cn |
EDUCATION
2005.09-2006.08 University of Cincinnati, M.S. (Statistics);
1997.09-2000.12 Tsinghua University, Ph.D;
1994.09-1997.06 Luoyang Institute of Technology, M.E;
1990.09-1994.07 Luoyang Institute of Technology, BS;
2003.04-2004.03 Visiting scholar in Department of Biomedical engineering, University of Michigan, USA.
2006.06-2008.08 Research Area Specialist Intermediate in University of Michigan, USA.
2008.09-present Associate Professor, Donghua University, P.R.China.
1. Hyperbranched polymer-based organic/inorganic hybrid nanoparticles for nanomedicinal applications including targeted drug delivery, molecular imaging and theranostics;
2. Multifunctional electrospun nanofibers for medical and environmental applications.
1. Mingwu Shen, Su He Wang, Xiangyang Shi*, Xisui Chen, Qingguo Huang , Elijah J. Petersen, Roger A. Pinto, James R. Baker, Jr., and Walter J. Weber, Jr. Polyethyleneimine-Mediated Functionalization of Multi-Walled Carbon Nanotubes: Synthesis, Characterization, and in vitro Toxicity Assay. J. Phys. Chem. C2009, 113(8), 3150-3156 (IF 4.536).
2. Mingwu Shen and Xiangyang Shi*. Dendrimer-based organic/inorganic hybrid nanoparticles in biomedical applications. Nanoscale2010, 2, 1596–1610 (IF 7.367).
3. Mingwu Shen, Kai Sun, Xiangyang Shi*. Hydroxylated dendrimer-stabilized gold and silver nanoparticles: Spontaneous formation, characterization, and properties. Curr. Nanosci.2010, 6, 307-314 (IF 1.062).
4. Mingwu Shen, Hongdong Cai, Xifu Wang, Xueyan Cao, Kangan Li, Su He Wang, Rui Guo, Linfeng Zheng, Guixiang Zhang*, Xiangyang Shi*. Facile one-pot preparation, surface functionalization, and toxicity assay of APTS-coated iron oxide nanoparticles. Nanotechnology2012, 23, 105601 (IF 3.440).
5. Yunpeng Huang, Hui Ma, Shige Wang, Mingwu Shen,* Rui Guo, Xueyan Cao, and Xiangyang Shi*. Efficient catalytic reduction of hexavalent chromium using palladium nanoparticle-immobilized electrospun polymer nanofibers. ACS Appl. Mater. Interfaces2012, 4(6), 3054-3061 (IF 7.504).
6. Hongdong Cai, Kangan Li, Mingwu Shen*, Shihui Wen, Yu Luo, Chen Peng, Guixiang Zhang*, Xiangyang Shi*. Facile assembly of Fe3O4@Au core-shell nanoparticles for dual mode magnetic resonance and computed tomography imaging applications. J. Mater. Chem.2012, 22, 15110–15120 (IF 6.626).
7. Yu Luo, Shige Wang, Mingwu Shen,* Ruiling Qi, Yi Fang, Rui Guo, Hongdong Cai, Xueyan Cao, Helena Tomás, Meifang Zhu, and Xiangyang Shi*. Carbon nanotube-incorporated multilayered cellulose acetate nanofibers for tissue engineering applications. Carbohydr. Polym.2013, 91, 419- 427 (IF 4.811).
8. Fuyin Zheng, Shige Wang, Shihui Wen, Mingwu Shen,** Meifang Zhu, Xiangyang Shi*. Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. Biomaterials2013, 34, 1402-1412 (IF 8.402).
9. Fuyin Zheng, Shige Wang, Mingwu Shen,* Meifang Zhu, Xiangyang Shi*. Antitumor efficacy of doxorubicin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. Polym. Chem., 2013, 4(4), 933-941 (IF 5.375).
10. Hongdong Cai, Xiao An, Jun Cui, Jingchao Li, Shihui Wen, Kangan Li, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang*, Xiangyang Shi*. Facile Hydrothermal Synthesis and Surface Functionalization of Polyethyleneimine-Coated Iron Oxide Nanoparticles for Biomedical Applications. ACS Appl. Mater. Interfaces2013, 5 (5), 1722–1731 (IF 7.504).
11. Hui Ma, Yunpeng Huang, Mingwu Shen*, Dengmai Hu, Hong Yang, Meifang Zhu, Shiping Yang, Xiangyang Shi*. Enhanced decoloration efficacy of electrospun polymer nanofibers immobilized with Fe/Ni bimetallic nanoparticles. RSC Adv.2013, 3, 6455–6465(IF 3.108).
12. Linfeng Zheng, Jingyi Zhu, Mingwu Shen,* Xisui Chen, James R. Baker, Jr., Su He Wang, Guixiangzhang,* and Xiangyang Shi*. Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles. Med. Chem. Commun.2013, 4(6), 1001-1005 (IF 2.608).
13. Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* and Xiangyang Shi*. Polyethyleneimine-Mediated Synthesis of Folic Acid-Targeted Iron Oxide Nanoparticles for in Vivo Tumor MR Imaging. Biomaterials2013, 34, 8382-8392 (IF 8.402).
14. Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Facile One-Pot Synthesis of Fe3O4@Au Composite Nanoparticles for Dual Mode MR/CT Imaging Applications. ACS Appl. Mater. Interfaces2013, 5(20), 10357-10366 (IF 7.504).
15. Yunpeng Huang, Dengmai Hu, Shihui Wen, Mingwu Shen,* Meifang Zhu, Xiangyang Shi*. Selective removal of mercury ions using thymine-grafted electrospun polymer nanofibers. New J. Chem.2014, 38 (4), 1533 - 1539 (IF 3.269).
16. Yun Zheng, Fanfan Fu, Mengen Zhang, Mingwu Shen,* Meifang Zhu, Xiangyang Shi*. Multifunctional dendrimers modified with alpha-tocopheryl succinate for targeted cancer therapy. Med. Chem. Commun.2014, 5(7), 879-885 (IF 2.608).
17. Jingchao Li, Yao He, Wenjie Sun, Hongdong Cai, Yunqi Pan, Mingwu Shen**, Jindong Xia***, Xiangyang Shi*. Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging. Biomaterials2014, 35, 3666-3677 (IF 8.402).
18. He Zhang, Jingchao Li, Wenjie Sun, Yong Hu, Guofu Zhang*, Mingwu Shen*, Xiangyang Shi*. Hyaluronic acid-modified magnetic iron oxide nanoparticles for MR imaging of surgically induced endometriosis model in rats. PLoS One2014, 9(4), e94718 (IF 2.806).
19. Kangan Li*, Mingwu Shen*, Linfeng Zheng, Jinglong Zhao, Qimeng Quan, Xiangyang Shi, Guixiang Zhang*. Magnetic Resonance Imaging of Glioma with novel APTS-Coated Superparamagnetic Iron Oxide Nanoparticles. Nanoscale Res. Lett.2014, 9, 304 (IF 2.833).
20. Yong Hu, Jingchao Li, Mingwu Shen*, Xiangyang Shi *. Formation of multifunctional Fe3O4/Au composite nanoparticles for dual mode MR/CT imaging applications*. Chin. Phys. B2014, 23(7), 078704 (IF 1.223).
21. Benqing Zhou, Linfeng Zheng, Chen Peng, Du Li, Jingchao Li, Shihui Wen, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Synthesis and characterization of PEGylated polyethyleneimine-entrapped gold nanoparticles for blood pool and tumor CT imaging. ACS Appl. Mater. Interfaces2014, 6, 17190−17199 (IF 7.504).
22. Jingchao Li, Xiangyang Shi,* Mingwu Shen*. Hydrothermal Synthesis and Functionalization of Iron Oxide Nanoparticles for MR Imaging Applications. Part. Part. Syst. Charact.2014, 31, 1223–1237 (IF 4.474).
23. Hui Liu+, Han Wang+, Yanhong Xu+, Rui Guo, Shihui Wen, Yunpeng Huang, Weina Liu, Mingwu Shen*, Jinglong Zhao, Guixiang Zhang*, and Xiangyang Shi*. Lactobionic Acid-Modified Dendrimer-Entrapped Gold Nanoparticles for Targeted CT Imaging of Human Hepatocellular Carcinoma. ACS Appl. Mater. Interfaces2014, 6, 6944−6953 (IF 7.504).
24. Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* Xiangyang Shi*. Hyaluronic Acid-Modified Fe3O4@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials2015, 38, 10-21 (IF 8.402).
25. Qian Chen, Han Wang, Hui Liu, Shihui Wen, Chen Peng, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Multifunctional Dendrimer-Entrapped Gold Nanoparticles Modified with RGD Peptide for Targeted Computed Tomography/Magnetic Resonance Dual-Modal Imaging of Tumors. Anal. Chem.2015, 87 (7), pp 3949–3956 (IF 6.320).
26. Yong Hu, Jingchao Li, Jia Yang, Ping Wei, Yu Luo, Ling Ding, Wenjie Sun, Guixiang Zhang*, Xiangyang Shi*, Mingwu Shen*. Facile synthesis of RGD peptide-modified iron oxide nanoparticles with ultrahigh relaxivity for targeted MR imaging of tumors. Biomater. Sci.2015, 3, 721-732 (IF 4.210).
27. Jingchao Li, Yong Hu, Jia Yang, Wenjie Sun, Hongdong Cai, Ping Wei, Yaping Sun,* Guixiang Zhang, Xiangyang Shi*, Mingwu Shen*. Facile synthesis of folic acid-functionalized iron oxide nanoparticles with ultrahigh relaxivity for targeted tumor MR imaging. J. Mater. Chem. B2015, 3, 5720 - 5730 (IF 4.543).
28. Yu Luo, Jia Yang, Yu Yan, Jingchao Li, Mingwu Shen,* Guixiang Zhang,* Serge Mignani, Xiangyang Shi*. RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T1-weighted MR imaging of glioma. Nanoscale2015, 7, 14538–14546 (IF 7.367).
29. Hongdong Cai, Kangan Li, Jingchao Li, Shihui Wen, Qian Chen, Mingwu Shen,* Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Dendrimer-Assisted Formation of Fe3O4/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors. Small2015, 11 (35), 4584-4593 (IF 8.643).
30. Yu Luo, Jia Yang, Jingchao Li, Zhibo Yu, Guixiang Zhang,* Xiangyang Shi*, Mingwu Shen *. Facile synthesis and functionalization of manganese oxide nanoparticles for targeted T1-weighted tumor MR imaging. Colloid Surf. B: Biointerfaces2015, 136, 506–513 (IF 3.887).
31. Hongdong Cai, Xiao An, Shihui Wen, Jingchao Li, Guixiang Zhang*, Xiangyang Shi*, Mingwu Shen*. Facile One-Pot Synthesis of Gd(OH)3-Doped Fe3O4 Nanoparticles for Dual-Mode T1- and T2-Weighted Magnetic Resonance Imaging Applications. Part. Part. Syst. Charact.2015, 32, 934–943 (IF 4.474).
32. Yong Hu, Jia Yang, Ping Wei, Jingchao Li, Ling Ding, Guixiang Zhang,* Xiangyang Shi,* Mingwu Shen*. Facile synthesis of hyaluronic acid-modified Fe3O4/Au composite nanoparticles for targeted dual mode MR/CT imaging of tumors. J. Mater. Chem. B 2015, 3, 9098-9108 (IF 4.543).
33. Lei Liu, Yili Zhao, Qian Chen, Xiangyang Shi,* Mingwu Shen*. The assembly of polyethyleneimine-entrapped gold nanoparticles onto filter paper for catalytic applications. RSC Adv.2015, 5, 104239-104244 (IF 3.108).
34. Jingchao Li, Yong Hu, Wenjie Sun, Yu Luo, Xiangyang Shi,* Mingwu Shen*. Facile preparation of hyaluronic acid-modified Fe3O4@Mn3O4 nanocomposites for targeted T1/T2 dual-mode MR imaging of cancer cells. RSC Adv.2016, 6, 35295-35304 (IF 3.108).
35. Yong Hu, Ruizhi Wang, Shige Wang, Ling Ding, Jingchao Li, Yu Luo, Xiaolin Wang,* Mingwu Shen*, Xiangyang Shi*. Multifunctional Fe3O4@Au Core/Shell Nanostars: A Unique Platform for Multimode Imaging and Photothermal Therapy of Tumors. Sci. Rep.2016, 6, 28325 (IF 4.259)
36. Xin Li, Zuogang Xiong, Xiaoying Xu, Yu Luo, Chen Peng*, Mingwu Shen*, and Xiangyang Shi*. 99mTc-Labeled Multifunctional Low Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT/CT Dual-Mode Imaging of Tumors. ACS Appl. Mater.Interfaces2016, 8, 19883-19891 (IF 7.504)
37. Benqing Zhou, Mingwu Shen*, István Bányai,* Xiangyang Shi*. Structural characterization of PEGylated polyethylenimine-entrapped gold nanoparticles: An NMR study. Analyst2016, 141, 5390 - 5397 (IF 3.885).
38. Wenjie Sun, Jia Yang, Jianzhi Zhu, Yiwei Zhou, Jingchao Li, Xiaoyue Zhu, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Immobilization of Iron Oxide Nanoparticles within Alginate Nanogels for Enhanced MR Imaging Applications. Biomater. Sci.2016, 4, 1422-1430 (IF 4.210).
39. Yu Luo, Lingzhou Zhao, Xin Li, Jia Yang, Lilei Guo, Guixiang Zhang, Mingwu Shen*, Jinhua Zhao*, Xiangyang Shi*. The design of a multifunctional dendrimer-based nanoplatform for targeted dual mode SPECT/MR imaging of tumors. J. Mater. Chem. B2016, 4, 7220-7225 (IF 4.543).
40. Wenjie Sun, Serge Mignani, Mingwu Shen*, Xiangyang Shi*. Dendrimer-based magnetic iron oxide nanoparticles: synthesis and biomedical applications. Drug Discovery Today2016, 21 (12), 1873-1885 (IF 6.369).
41. Ping Wei, Jingwen Chen, Yong Hu, Xin Li, Han Wang*, Mingwu Shen*, Xiangyang Shi*. Dendrimer-Stabilized Gold Nanostars as a Multifunctional Theranostic Nanoplatform for CT Imaging, Photothermal Therapy, and Gene Silencing of Tumors. Adv. Healthcare Mater.2016, 5 (24), 3203-3213 (IF 5.110).
42. Yong Hu#, Ruizhi Wang#, Jingchao Li, Ling Ding, Xiaolin Wang,* Xiangyang Shi,* Mingwu Shen*. Facile Synthesis of Lactobionic Acid-Targeted Iron Oxide Nanoparticles with Ultrahigh Relaxivity for Targeted MR Imaging of an Orthotopic Model of Human Hepatocellular Carcinoma. Part. Part. Syst. Charact.2017, 34, 1600113 (IF 4.474).
43. Xin Li#, Lingxi Xing#, Kailiang Zheng, Ping Wei, Lingzhou Zhao, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. Formation of Gold Nanostar-Coated Hollow Mesoporous Silica for Tumor Multi-Modality Imaging and hotothermal Therapy. ACS Appl. Mater. Interfaces2017, 9, 5817−5827 (IF 7.504).
44. Du Li, Jia Yang, Shihui Wen, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles. J. Mater. Chem. B2017, 5, 2395-2401 (IF 4.543).
45. Xin Li, Lingxi Xing, Yong Hu, Zhijuan Xiong, Ruizhi Wang, Xiaoying Xu, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. An RGD-modified hollow silica@Au core/shell nanoplatform for tumor combinational therapy. Acta Biomater.2017, 62, 2017, 273-283 (IF 6.319).
46. Jingchao Li, Shige Wang, Xiangyang Shi,* Mingwu Shen*. Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy. Adv. Colloid Interface Sci.2017, 249, 374–385 (IF 7.223).
47. Benqing Zhou, Zuogang Xiong, Peng Wang, Chen Peng*, Mingwu Shen*, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*.Targeted tumor dual mode CT/MR imaging using multifunctional polyethylenimine-entrapped gold nanoparticles loaded with gadolinium. Drug Delivery2018, 25, 178-186 (IF 6.402).
48. Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, and Xiangyang Shi*.Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev.2018, In press (IF 38.618).
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