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东华大学材料学院复合材料系主任,博导

教育背景

  • 1996-2000上海交通大学化学化工学院应用化学学士学位

  • 2002-2007中国科学院上海有机化学研究所有机化学博士学位

工作经历

  • 2016-至今东华大学复合材料系系主任

  • 2013-至今东华大学材料科学与工程学院教授

  • 2012-2013 拜耳材料科技亚太区新事业企划部创新经理

  • 2011-2012美国匹兹堡大学生物工程系访问研究助理教授

  • 2009-2011美国匹兹堡大学生物工程系博士后

  • 2007-2008美国佐治亚理工学院生物医学工程系博士后

  • 2000-2002上海交通大学化学化工学院教师

社会任职

  • 2018-至今中国医药教育协会医用生物材料与技术专业委员会委员

  • 2018-至今中国机械工程学会生物制造工程分会委员

  • 上海市侨联青年总会常务理事

  • 2019-至今上海市生物医学工程学会生物材料专业委员会委员

代表论文

1. Wang, S.#; Liu, Z.#; Guo, Y.; Song, J.; Lou, J.; Guan, Q.; He, C.; You, Z.* Strong, detachable, and self-healing dynamic crosslinked hot melt polyurethane adhesive Mater. Chem. Front. 2019, 3, 1833-1839.

2. Yang, Y.#, Lei, D.#, Huang S., Yang Q., Li S., Qing, F.-L., Ye X.*, You, Z.*, Zhao, Q.* Hybrid electrospun rapamycin-loaded small-diameter vascular grafts effectively inhibit intimal hyperplasia Acta Biomater. DOI: 10.1016/j.actbio.2019.06.037.

3.Nanofibrous vascular scaffold prepared from miscible polymer blend with heparin/stromal cell-derived factor-1 alpha for enhancing anticoagulation and endothelialization  Colloids and Surfaces B: Biointerfaces

4. Sun, L; Chen, S.; Guo, Y. Song, J.; Zhang, L.; Xiao, L.; Guan, Q.; You, Z.* Ionogel-based, highly stretchable, transparent, durable triboelectric nanogenerators for energy harvesting and motion sensing over a wide temperature range Nano Energy, 2019, 63, 103847.

5. Liu, Z.#; Zhang, L.#; Guan, Q.; Guo, Y.; Lou, J.; Lei, D.; Wang, S.; Chen, S.; Sun, L.; Xuan, H.; Jeffries, E.; He, C.; He, C.; Qing, F.-L.; You, Z.* Biomimetic materials with multiple protective functionalities Adv. Funct. Mater.2019, 1901058.

6. Zhang, L.#; Liu, Z.#; Wu, X.; Guan, Q.; Chen, S.; Sun, L.; Guo, Y.; Wang, S.; Song, J.; Jeffries, E.; He, C.; Qing, F.-L.; Bao, X.; You, Z.* A highly efficient self-healing elastomer with unprecedented mechanical properties Adv. Mater.2019, 1901402

7. Guan, Q.; Gong, Y.; Lin, G.; Wang, J.; Tan, W.; Bao, D.; Liu, Y.; You, Z.; Sun, X.; Wen, Z.*; Pan, Y.* Highly efficient self-healable and dual responsive hydrogel-based deformable triboelectric nanogenerators for wearable electronics J. Mater. Chem. A, 2019, 7 (23), 13948-13955

8. Ye, K.; Kuang, Z.; You, Z.; Morsi, Y.; Mo, X.* Electrospun Nanofiber for Tissue Engineering with Drugs Loading and Release Pharmaceutics2019, 11, 182.

9. Yang. Y#; Lei, D.#; Huang, S.; Yang, Q.; Song, B.; Guo, Y.; Shen, A.; Yuan, Z.; Li, S.; Qing, F-L.; Ye, X.*; You, Z.*; Zhao, Q.* Elastic 3D printed hybrid polymeric scaffold improves cardiac remodeling after myocardial infarction Adv. Healthc. Mater. 2019, 1900065.

10. Xie, Y.; Lei, D.; Wang, S.; Liu, Z.; Sun, L.; Zhang, J.; Qing, F-L.; He, C.*; You. Z.* A biocompatible, biodegradable and functionalizable copolyester and its application in water-responsive shape memory scaffold ACS Biomater. Sci. Eng.2019, DOI: 10.1021/acsbiomaterials.8b01337

11. Lei, D.; Yang, Y.; Liu, Z.; Yang, B.; Gong, W.; Chen, S.; Sun, L.; Song, B.; Xuan, H.; Mo, X.; Sun, B.; Li, S.; Yang, Q.; Huang, S.; Chen, S.; Ma, Y.; Liu, W.; He, C.; Zhu, B.; Jeffries, E.; Qing, F-L.; Ye, X.*; Zhao, Q.*; You, Z.* 3D printing of biomimetic vasculature for tissue regeneration Mater. Horiz.2019, DOI: 10.1039/C9MH00174Cs

12. Xiao, B.#; Yang, W. #; Yang, W.; Lei, D.; Huang, J.; Yin, Y.; Zhu, Y.; You, Z.*; Wang, F.*; Sun, S.* PGS scaffolds promote the in vivo survival and directional differentiation of bone marrow mesenchymal stem cells restoring the morphology and function of the wounded rat uterus Adv. Healthc. Mater. 2019, DOI 10.1002/adhm.201801455 (#Co-first author)

13. Zhu, J.; Xia, K.; Yu, W.; Wang, Y.; Hua, J.; Liu, B.; Gong, Z.; Wang, J.; Xu, A.; You, Z.; Chen, Q.; Li, F.; Tao, H.; Liang, C.*Sustained release of GDF5 from a designed coacervate attenuates disc degeneration in a rat model Acta Biomater. 2019, 86, 300-311

14. Chen, H.; Zhang, J.; Zhou, X.; Yang, S.; Zhang Q.; Wang, Wang, W.; You, Z.; Peng, C.; He, C.* Merging metal organic framework with hollow organosilica nanoparticles as a versatile nanoplatform for cancer theranostics, Acta Biomater. 2019, 86, 406-415

15. Guo, X.; Zhu, J.; Zhang, H.; You, Z.; Morsi, Y.; Mo, X.*, Zhu, T. Facile preparation of a controlled-release tubular scaffold for blood vessel implantation, J. Colloid Interf. Sci.2019, 539, 351-360

16. Guo, Y.#; Lv, Z.#; Huo, Y.; Sun, L.; Chen, S.; Liu, Z.; He, C.; Bi, X.; Fan, B. You Z.*A biodegradable functional water-responsive shape memory polymer for biomedical applications J. Mater. Chem. B, 2019, 7, 123-132.

17. Sun, L.; Wang, M.; Chen, S.; Sun, B.; Guo, Y.; He, C.; Mo, X.; Zhu, B.; You, Z.*; Molecularly engineered metal-based bioactive soft materials – neuroactive magnesium ion/polymer hybrids Acta Biomater.2019, 85, 310-319.

18. Lei, D.; Yang, Y.; Chen, S.; Liu, Z.; Song, B.; Shen, A.; Yang, B.; Li, S.; Yuan, Z.; Qi, Q.; Sun, L.; Guo, Y.; Zuo, H.; Huang, S.; Yang, Q.; Mo, X.; He, C.; Zhu, B.; Jeffries, E.; Qing, F-L.; Ye, X.*; Zhao Q.*; You, Z.* A general strategy of 3D printing thermosets for diverse applications Mater. Horiz., 2019, 6, 394-404.

19. Chen, S.#; Huang, T.#; Zuo, H.; Qian, S.; Guo, Y.; Sun, L.; Lei, D.; Wu, Q.; Zhu, B.; He, C.; Mo, X.; Jeffries, E.; Yu, H.; You, Z.* A single integrated 3D-printing process customizes elastic and sustainable triboelectric nanogenerators for wearable electronics Adv. Funct. Mater.2018, 28, 1805108. (Back Cover)

20. Wang, W.; Nie, W.; Zhou, X.; Feng, W.; Chen, L.; Zhang, Q.; You, Z.; Shi, Q.; Peng, C.; He, C.; Fabrication of heterogeneous porous bilayered nanofibrous vascular grafts by two-step phase separation technique Acta Biomater.2018, 79, 168-181.

21. Liu, Z.; Huang, J.; Sun, L.; Lei, D.; Cao, J.; Chen, S.; Shih, W.; Qing, F.*; You, Z.* PPC-based reactive hot melt polyurethane adhesive (RHMPA) – efficient glues for multiple types of substrates. Chinese J. Polym. Sci. 2018, 36, 58-64.

22. Fang, J.; Zhao, H.; Liu, Q.; Zhang, W.; Gu, J.; Su, Y.; Abbas, W.; Su, H.; You, Z.; Zhang, D.* AgBr/diatomite for the efficient visible-light-driven photocatalytic degradation of Rhodamine B J. Nanopart. Res. 2018, 20, 61.

23. Geng, Z.; Yang, S.; Zhang, L.; Huang, Z.; Pan, Q.; Li, J.; Weng, J.; Bao, J.; You, Z.; He, Y.; Zhu, B.* Self-extinguishing resin transfer molding composites using non-firee-retardant epoxy resin Materials2018, 11, 2554.

24. Wang, M.#; Lei, D.#; Liu, Z.#; Chen, S.; Sun, L.; Lv, Z.; Huang, P.; Jiang, Z.*; You, Z.* A poly(glycerol sebacate) based photo/thermo dual curable biodegradable and biocompatible polymer for biomedical applications. J. Biomat. Sci. – Polym. E. 2017, 28, 1728-1739.

25. Ding, Y.#; Sun, Y.#; Lv, Z.#; Sun, H.; Bi, X.; Lu, L.; Zhou, H.; You, Z.; Wang, Y.; Ruan, J.*; Gu, P.*; Fan, X.* Poly (fumaroyl bioxirane) maleate: A potential functional scaffold for bone regeneration. Mater. Sci. and Eng.: C. 2017, 76, 249-259. (#Co-first author)

26. Wei, W.#; Li, J.#; Chen, S.#; Chen, M.; Xie, Q.; Sun, H.; Ruan, J.; Zhou, H.; Bi, X.; Zhuang, A.; You, Z.*; Gu, P.*; Fan, X.* In vitro osteogenic induction of bone marrow mesenchymal stem cells with a decellularized matrix derived from human adipose stem cells and in vivo implantation for bone regeneration. J. Mater. Chem. B, 2017, 5, 2468-2482. (#Co-first author).

27. Chen, S.; Bi, X.; Sun, L.; Gao, J.; Huang, P.; Fan, X.; You, Z.*; Wang, Y.* Poly(sebacoyl diglyceride) cross-Linked by dynamic hydrogen bonds: A self-healing and functionalizable thermoplastic bioelastomer. ACS Appl. Mater. Interfaces2016, 8(32), 20591–20599.

28. Ni, N.#; Ji, J.#; Chen, S.#; Zhang, D.; Wang, Z.; Shen, B.; Guo, C.; Zhang, Y.; Wang, S.; Fan, X.; You, Z.*; Luo, M.*; Gu, P.*Poly(1,3-propylene sebacate) and poly(sebacoyl diglyceride): a pair of potential polymers for the proliferation and differentiation of retinal progenitor cellsMacromol. Biosci. 2016, 16, 1334-1347.

29. Wang, S.; Jeffries, E.; Gao, J.; Sun, L.;You, Z.*; Wang. Y.* Polyester with pendent acetylcholine-mimicking functionalities promotes neurite growth. ACS Appl. Mater. Interfaces, 2016, 8(15), 9590-9599.

30. Huang, P.; Bi, X.; Gao, J.; Sun, L.; Wang, S.; Chen, S.; Fan, X.*; You, Z.*; Wang. Y.* Phosphorylated poly(sebacoyl diglyceride) - a phosphate functionalized biodegradable polymer for bone tissue engineering.J. Mater. Chem. B, 2016, 4(12), 2090-2101 (Front cover).

31. Gong, W.#; Lei, D.#; Li, S.; Huang, P.; Qi, Q.; Sun, Y.; Zhang, Y.; Wang, Z; You, Z.*; Ye, X.*; Zhao, Q.* Hybrid small-diameter vascular grafts: Anti-expansion effect of electrospun poly ε-caprolactone on heparin-coated decellularized matrices. Biomaterials2016, 76, 359-370.

32. Gong, W.; Li, S.; Lei, D.; Huang, P.; Yuan, Z.; You, Z.; Zhao, Q.*; Ye, X.* Tissue-engineered mitral valve chordae tendineae: biomechanical and biological characterization of decellularized porcine chordae. J. Mech. Behav. Biomed. Mater. 2015, 56, 205-17.

33. Xie, Q.; Wang, Z.; Huang, Y.; Bi, X .; Zhou, H.; Lin, M.; Yu, Z.; Wang, Y.; Ni, N.; Sun, J.; Wu, S.; You, Z.; Guo, C.; Sun, H.; Wang, Y.; Gu, P.*; Fan, X.*, Characterization of human ethmoid sinus mucosa derived mesenchymal stem cells (hESMSCs) and the application of hESMSCs cell sheets in bone regeneration. Biomaterials2015,66, 67-82.

34. Bi, X. #; You, Z.#; Gao, J.; Fan, X.*; Wang, Y.*A functional polyester carrying free hydroxyl groups promotes the mineralization of osteoblast and human mesenchymal stem cell extracellular matrix. Acta Biomater. 2014, 10(6), 2814-23. (#Co-first author).

35. Deng, Y.; Bi, X.; Zhou, H.; You, Z.; Wang, Y.; Gu, P.; Fan, X.*Repair of critical-sized bone defects with anti-miR-31-expressing bone marrow stromal stem cells and poly(glycerol sebacate) scaffolds. Eur. Cells Mater.2014, 27, 13-25.

36. Chen, J.; You Z.; Qing, F.* Total synthesis of γ-trifluoromethylated analogs of goniothalamin and their derivatives. J. Fluorine Chem. 2013, 155, 143-150.

37. Yang, Y.; You, Z.; Qing, F.* Design and synthetic investigation toward gem-difluoromethylenated fostriecin analogue. Acta Chim. Sinica. 2012, 70, 2323-2336.

38. You, Z.; Wang, Y.*A versatile synthetic platform for a wide range of functionalized biomaterials. Adv. Funct. Mater. 2012, 22, 2812-2820.

39. You, Z.;Bi, X.; Wang, Y.*Fine control of polyester properties via epoxide ROP using monomers carrying diverse functional groups. Macromol. Biosci. 2012, 12, 822-829.

40. You, Z.; Bi, X.; Fan, X.*; Wang, Y.*A functional polymer designed for bone tissue engineering. Acta Biomater.2012, 8, 502-510.

41. You, Z.; Bi, X.; Jeffries, E. M.; Wang, Y.* A biocompatible, metal-free catalyst and its application in microwave-assisted synthesis of functional polyesters. Polym. Chem. 2012, 3, 384-389.

42. You, Z.; Cao, H.; Gao, J.; Paul, S. H.; Day, B. W.; Wang, Y.* A functionalizable polyester with free hydroxyl groups and tunable physiochemical and biological properties. Biomaterials 2010, 31, 3129-3138.

43. Xie, Y.; Xu, X.; Yue, X.; You, Z.; Qing, F.* Synthesis of gem-difluoromethylenated goniodiol. Chin. J. Org. Chem. 2008, 28, 283-287.

44. Yang, Y.; Xu, J.; You, Z.; Xu, X.; Qiu, X.; Qing, F.*Synthesis of 3΄,3΄-difluoro-2΄-hydroxymethyl-4΄,5΄-unsaturated carbocyclic nucleosides. Org. Lett.2007, 9, 5437-5440.

45. Wang, B.; Jiang Z.; You, Z.; Qing, F.* Total synthesis of trifluoromethylated analogs of macrosphelide A. Tetrahedron 2007, 63, 12671-12680.

46. Xu, X.; You, Z.; Zhang, X.; Qing, F.* Synthesis of 3-deoxy-3,3-difluoro-D-ribohexose from gem-difluorohomoallyl alcohol. J. Fluorine Chem. 2007, 128, 535-539.

47. You, Z.; Jiang, Z.; Wang, B.; Qing, F.* An efficient and general route to gem-difluoromethylenated α, β-unsaturated δ-lactones: high enantioselective synthesis of gem-difluoromethylenated goniothalamins. J. Org. Chem. 2006, 71, 7261-7267.

48. You, Z.; Zhang, X.; Qing, F.* Stereocontrolled synthesis of gem-difluoromethylenated goniodiols and goniothalamin epoxides based on ring-closing metathesis. Synthesis, 2006, 15, 2535-2542.

49. You, Z.; Wu, Y.; Qing, F.* Synthesis of gem-difluoromethylenated massoialactone by ring-closing metathesis. Tetrahedron Lett. 2004, 45, 9479-9481.

部分专利申请

1.游正伟、黄鹏,一种可降解磷酸化材料及其制备方法和成骨应用,中国发明专利,授权专利号:ZL201510271968.2

2.游正伟、王少飞、陈硕、谷平、倪妮,一种聚(13-丙二醇-癸二酸酯)在制备视网膜神经细胞载体中的应用,中国发明专利,授权专利号:ZL201510325707.4

3.游正伟、陈硕、王少飞、谷平、倪妮,一种聚(癸二酰基甘油二酯)在制备视网膜神经细胞载体中的应用,中国发明专利,授权专利号:201510323993.0

4.游正伟、黄鹏、王少飞,一种易功能化易加工的超分子生物弹性体及其制备方法,中国发明专利,授权专利号:ZL201510362569.7

5.游正伟、黄鹏、赵强、叶晓峰、王敏、龚文辉,一种可降解光固化医用粘合剂及其制备和应用,中国发明专利,授权专利号:ZL201510992697X

6.游正伟、王少飞,一种可降解主链季铵盐型聚阳离子及其制备方法,中国发明专利,授权专利号:ZL2015109606083

7.王少飞、游正伟黄鹏、褚江、陈硕、耿聪颖、王敏,一种血管修复装置,中国发明专利,授权专利号:ZL2015102705637

8.游正伟、谢阳芬、王少飞,一种功能化脂肪芳香共聚酯及其制备方法,中国发明专利,授权专利号:ZL201611065565.3

9.游正伟、梁嘉辉,一种功能化聚酯聚氨酯间聚物及其制备和应用,中国发明专利,授权专利号:ZL201710237267.6

10.游正伟、轩慧霞、耿聪颖,一种PPS/PGS复合材料形状记忆弹性体的制备方法,中国发明专利,授权专利号:ZL201710249067.2

11.游正伟、范先群、毕晓萍、谷平、郭一凡, 一种用于眼眶骨缺损修复的塞型多孔支架,中国实用新型专利,授权专利号:ZL201621234052.6

12.游正伟、黄鹏、王少飞、谷平、范先群,一种用于骨缺损修复的多孔支架,中国实用新型专利,授权专利号:ZL201506277431

13.游正伟王少飞、陈励捷,一种复合结构小口径管状多孔支架及其制备方法,中国发明专利,申请号:201610396911.X

14.正伟、王少飞,一种用于与粉体复合的聚氨酯胶水,中国发明专利,申请号:201611096556.0

15.耿聪颖、游正伟,一种聚(癸二酸甘油二酯)的应用,中国发明专利,申请号:2017100604310

16.游正伟、郭一凡,一种手性聚(癸二酰基甘油二酯)的制备方法,中国发明专利,申请号:201710244314X

17.游正伟、耿聪颖、轩慧霞,一种聚(癸二酰基甘油二酯)形状记忆弹性体的制备方法,中国发明专利,申请号:2017102492998

18.游正伟、雷东,一种多级结构仿生血管网络组织工程支架的制备方法,中国发明专利,申请号:2017102851026

19.游正伟、雷东,一种具有多级孔隙结构的热固性弹性体组织工程支架的制备方法,中国发明专利,申请号:201710348151X

20.游正伟、吕姿颖,一种PFB水响应形状记忆组织工程支架及其制备方法,中国发明专利,申请号:20170570540.7

21.游正伟、吕姿颖,一种PFOE水响应形状记忆组织工程支架及其制备方法,中国发明专利,申请号:201710571655.8

22.游正伟、刘增贺,一种聚碳酸亚丙酯基湿固化聚氨酯热熔胶及其制备方法,中国发明专利,申请号:2017102963873

23.游正伟、陈硕,一种仿生增韧生物弹性体及其制备方法,中国发明专利,申请号:2017103588663

24.游正伟黄鹏、王少飞,一种用于促进损伤子宫恢复的PGS/BMSCs复合支架及其制备方法,中国发明专利,申请号:201710787174

25.游正伟、吕姿颖,一种功能化聚酯及其三维多孔支架以及制备方法,中国发明专利,申请号:201810161856.5

26.游正伟、陈硕,一种聚(癸二酸甘油酯)3D打印纳米发电机及其制备方法和应用,中国发明专利,申请号:201810940007X

27.游正伟、张璐之、刘增贺,一种自修复聚氨酯及其制备方法,中国发明专利,申请号:2018115820675

28.游正伟、轩慧霞、宋建春、楼佳铭、左涵,一种具有生物活性的自愈合形状记忆多孔支架及其制备方法和应用,中国发明专利,申请号:2018114730192

29.游正伟、王署亮,一种含有肟氨酯动态键的聚氨酯热熔胶黏剂及其制备方法,中国发明专利,申请号:2019101075366

30.游正伟、雷东、叶晓峰、赵强,一种43D打印管状医用支架及其制备方法和应用,中国发明专利,申请号:2019100931665

31.游正伟刘增贺,一种多功能多重防护材料及其制备方法,中国发明专利,申请号:201910279664.9

学术专著

You, Z.; Wang, Y.* Book Chapter “Bioelastomers in Tissue Engineering”, in Biomaterials for Tissue Engineering: A Review of the Past and Future Trends, Burdick J. and Mauck R. L. Eds. (Springer-WienNew York, 2011,ISBN: 978-3-7091-0384-5) p. 75-118. DOI: 10.1007/978-3-7091-0385-2_4


承担的部分科研项目

1.国家重点研发计划(2018YFB1105600),血管化仿生关节多细胞精准3D打印技术与装备的开发及应用,2018/1-2020/12参与

2.东华大学励志计划(LZA2019001),功能弹性体,2019/1-2021/12主持

3. 上海市自然科学基金(18ZR1401900),仿生杂化交联策略构筑强韧动态共价生物弹性体,2018/06-2021/5主持

4. 国家自然科学基金面上项目(21574019),强韧、手性和氢键交联超分子聚(癸二酸甘油酯)骨架生物弹性体的研制,2016/01-2019/12主持

5. 国家自然科学基金青年基金项目(21304015),新型成骨诱导性磷酸化聚酯聚氨酯间聚物纳米纤维支架的设计制备及其在无细胞骨组织工程中的应用,2014/01-2016/12主持

6. 上海市自然科学基金(13ZR1401200),新型生物活性系列功能化脂肪芳香共聚酯的设计、合成及测试,2013/07-2016/6主持

7. 高等学校博士点基金(20130075120009),导向骨再生的功能化脂肪族芳香族共聚酯的设计、合成和体外测试,2014/01-2016/12主持

8. 国家高技术研究发展计划(863计划)项目(2015AA020311),控释生长因子和诱导眶骨再生的功能化智能材料的研发及临床研究,2015/01-2017/12,排名第二

9.国家自然科学基金重大国际合作研究项目(81320108010),基于微环境特点构建眼眶骨和粘膜复合体及其调控机制研究,2014/01-2018/12,合作单位负责人

10. 国家自然科学基金(31271029),基于PSeD马来酸酯生物活性控释支架复合生长因子构建眼眶组织工程骨的研究,2013/01-2016/12,参与

11. 中央高校基本科研业务费专项资金重点计划项目(2232014A3-01),基于微环境特点构建多功能生物材料修复眼眶骨,2014.1-2016.12,主持

12.东华大学励志计划(B201303),功能生物材料的构建及其应用,2014/1-2016/12,主持

13.拜耳材料科技委托研发项目, 高性能***纤维的制备及其在复合板材中的应用, 2015/01-2016/06,主持

14. 宁夏伊品生物科技股份有限公司委托研发项目,***生物基聚酰胺***2016/12-2017/12,主持

15.美国国防部“先进再生医学”研究基金(W81XWH-10-1-0618),导向血管化骨再生的组织工程支架(Scaffolds for vascularized bone regeneration)2010/04-2012/03,项目负责人


获奖

3D打印热固性材料及其心肌组织工程和智能化应用》中国化纤协会恒逸基金优秀论文二等奖